RNF130, an E3 ubiquitin ligase, has homology with regulators of endocytosis & protein-protein interactions. In murine models, genetic deficiency / disruption / silencing of Rnf130 leads to reduced LDL-C via LDLR upregulation ahajournals.org/doi/abs/10.116… Circulation Research

Circulation Research March 31st Issue is Out! ahajrnls.org/3wPOBJJ Cover: RNF130/GOLIATH regulates abundance & availability of the LDLR (green) at the plasma membrane by ubiquitinating LDLR causing redistribution away from the membrane & decreased LDL uptake (red/merge).

Excited to be on the #cover of Circulation Research this week with a cool story of regulation of LDLR abundance and availability! #GOLIATH #RNF130 #ubiquitination tags LDLR for cellular redistribution. Check it out now!

The gift that keeps on giving! Listen to our Circulation Research podcast out now and learn all about our #GOLIATH undertakings in the lab over the past few years! @BethanClifford Kelsey Jarrett, Ph.D. lizzietphd Department of Medicine at UCLA Health #ScienceTwitter #proudPI

Congrats to our grad student @gab_rubert!

ZFP36-mediated mRNA decay regulates metabolism dlvr.it/SnD02D

🏆#UCLAMicrobiome Center Seed Fellowship Award 2024 Intestinal #Microbiome & Bile Acid Dependency Through the Lens of Metabolic Dysfunction-Associated Steatotic #Liver Disease 🌟Rochelle Lai, MS, RD, PhD Student, UCLA Molecular, Cellular & Integrative Physiology 👤Mentor: The Tarling-Vallim Lab 👉bit.ly/41dd61g

If you enjoy bile acids, then this will be a fun read and a resource for you. It shows that we can begin using untargeted metabolomics big data mining using a mass spec query language to discover new molecules in animals and humans. cell.com/cell/fulltext/…

We are honored and excited to have Daisy Sahoo as our new Dean!

#UCLAGI 💙 getting together with our alumni, faculty, fellows, researchers and collaborators each year at the Digestive Disease Week! Thank you to everyone who joined us at the National Museum of Women in the Arts (Women in the Arts (NMWA)). So fun to catch up at #DDW2024!

Join us in celebrating Dr. Elinor Lee, awarded a K08 grant for her research on surfactant in lung diseases. Her research aims to address critical gaps in knowledge about the causal mechanisms of conditions like PAP and to transform treatment strategies. uclahs.fyi/4bWPLEF

Congrats to the Tarling-Vallim lab members for their outstanding leadership at the Gordon Research Conference on lipoprotein metabolism! We're proud to highlight that Dr. Tarling and Dr. Vallim will be chairing upcoming editions of this prestigious event! uclahs.fyi/3yby1aP

Meet Rochelle Lai, MS, RD, CSP! 💙💛 She's a clinical dietitian who's pursuing a PhD in the Molecular, Cellular & Integrative Physiology program. The Tarling-Vallim Lab UCLA Health Department of Medicine at UCLA Health youtube.com/watch?v=kQVhs5…

Reexamining the Role of Pulmonary Lipids in the Pathogenesis of Pulmonary Fibrosis American Thoracic Society (ATS) 🔗 tinyurl.com/3pahkz2t

The Lawrence Lab website (lawrence-lab.org) is live and we are hiring! We combine high resolution structure🔬 and cell biology🧫🧪 approaches to define mechanisms of stress response signaling in health and disease. Live postings at technician and postdoc levels: PLZ RT!

#TLM24 Poster! Friday, November 15, 1–2 pm Manipulating Bile Acid Pool Size to Target Dietary Fat Absorption in #MASLD 🌟Alvin Chan, MD, MPH (Alvin Chan MD MPH) 👥Kelsey Jarrett, Ph.D. R Lai M Brearley-Sholto A Lau A Cheng M Taveras A Iwata M Steel The Tarling-Vallim Lab

Last day of #AHA24 - feeling bittersweet as we wrap up an incredible few days of learning, networking, friendship, & more. Don’t worry, we’ve got one last fantastic event ahead: the ATVB Annual Award Ceremony, where we get to honor amazing Council Members like the ones below 🎊

Congratulations Liz Tarling of The Tarling-Vallim Lab lab for this recognition of your scientific and community contributions at AHA!!! Department of Medicine at UCLA Health David Geffen School of Medicine at UCLA UCLA Health UCLA Women in Cardiology

We're proud to celebrate Dr. Elizabeth Tarling who was honored with the American Heart Association ATVB Council Special Recognition Award in Vascular Biology for 2024. This award underscores her impactful research in lipid metabolism and heart disease: uclahs.fyi/3VkYDyx