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An elegant & fantastic review of the evolutionary biology that grounds anti-cancer strategies in Cancer Discovery! Lots to chew on. Love evolutionary double bind strategy; Drug 1 drives cells to homogeneous profile -> 2nd drug eradicates this population #LCSM Chat OncoAlert LungCancerRx 🫁💊

Zongertinib in #HER2 NSCLC simultaneous publication NEJM with #AACR25 presentation by Dr. John Heymach. In previously treated HER2 TKD mt NSCLC, RR 71%, duration of response 14.1m, mPFS 12.4m. G3 AEs in only 17% - diarrhea in 56% of pts but only 1 single case of G3 or higher.

Science has never brought me to tears until today. This poster was presented at #AACR25. The study used a cell line based on paired molecular profiling of biopsies derived from my dear friend Ivy Elkins cancer. Ivy's voice helped shape research, and now her cells are helping

I couldn’t be more excited to be starting my thoracic oncology career at CU Cancer Center as part of an incredible group featuring D. Ross Camidge, Tejas Patil, Erin Schenk, MD, PhD, Kyle Concannon, MD, and Paul Bunn!

Come on #ASCO25, this 💯 should have been a plenary! 7% improvement in 8-yr OS w exercise in adjuvant colon ca, greater than benefit for adding oxali to 5-FU (5% at 10 yrs in MOSAIC). Exercise = $ effective, ~0 tox, & gives pts sense of empowerment. Congrats Chris Booth et al!

Being part of a history-making drug that helps pts with #SCLC live longer and better is the biggest reward a thoracic oncologist could hope for. Grateful being involved and to our pts Just out in NEJM Presentation today by 1@only Charlie Rudin #ASCO25

Sanjay Popat Peter Mac Radiation Oncology Shankar Siva It’s impressive how nearly every study on NSCLC and SCLC using concurrent RT-IO has failed, with perhaps the only exception being the phase 2 KN799 trial for stage 3. While we still lack a clear biological explanation, the clinical evidence remains very consistent.