New Research: Brain organoid methodologies to explore mechanisms of disease in progressive multiple sclerosis frontiersin.org/articles/10.33… #FrontiersIn #CellularNeuroscience

CellAge Database of Cell #Senescence Genes genomics.senescence.info/cells/ 279 Senescence-associated genes 869 Longevity-associated genes A multidimensional systems biology analysis of cellular senescence in aging and disease Cleo Bishop Lab João Pedro de Magalhães Genome Biology 2020

Chronological versus immunological aging: Immune rejuvenation to arrest cognitive decline cell.com/neuron/fulltex…

onlinelibrary.wiley.com/doi/10.1111/jn…

🌟 Review alert: Curious about the role of the ChP in multiple sclerosis (MS) neuropathology🧠? Check out Alexandra Hochstetler, PhD review on how the ChP regulates CSF💧immune infiltration and signature + contributes to CSF composition in MS. pmc.ncbi.nlm.nih.gov/articles/PMC11…

And it's out! The BIC lab presents our new perspective article on "Immune Control of Brain Physiology" - fresh off the press at Nature Rev Immunol nature.com/articles/s4157… wonderful synergy Mariángeles Kovacs Samir and twitterless Amaia Dominguez-Belloso.

Macrophage-derived CTSS drives the age-dependent disruption of the blood-CSF barrier: Neuron cell.com/neuron/fulltex…

Senescent cells in the choroid plexus may be responsible for age-related weakening of the blood-CSF barrier. They trigger macrophages to release a protease that breaks down tight junctions. #alzheimersdisease Science | CAS Dubai ow.ly/503850Vbbx7

Excited to finally have this published! Out today in Nature Communications, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. nature.com/articles/s4146… 1/3

The brain & immune system are more connected than ever imagined. In this issue of Immunity, 9 articles explore major advances & future directions in neuroimmunology. Take a look! hubs.li/Q03lzQ3H0

🚨 New in Nature Communications: We present a spatial multi-omics platform that maps the metabolome, lipidome, and glycome from a single brain section. Combining MALDI imaging with our computational tool Sami, we reveal metabolic diversity in health and Alzheimer's disease. 🔗

Excited to share our new paper in J Transl Med: …nslational-medicine.biomedcentral.com/articles/10.11… ICV delivery of fetal-derived neural stem cells is safe and may slow disease in SOD1 ALS mice. A small step in a bigger fight. Grateful to all involved, and fitting timing during #ALSAwarenessMonth

Led by Ya'el Courtney, PhD and out today in Nature Neuroscience: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread rdcu.be/eoaSY

'Early #transcriptional and cellular abnormalities in choroid plexus of a mouse model of #AlzheimersDisease' Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao …arneurodegeneration.biomedcentral.com/articles/10.11…

Online now: Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain dlvr.it/TL86Y7

"[E]nlarged [choroid plexus] may contribute to brain damage accumulation, partially through impaired #glymphatic system clearance. If confirmed... processes...could represent novel therapeutic targets for...detrimental effects of #MS on🧠damage& irreversible clinical disability."

Hepatitis C Found in Brain Lining Linked to Schizophrenia, Bipolar Disorder A new study reveals hepatitis C virus (HCV) in the brain lining of people with schizophrenia and bipolar disorder, suggesting infection may play a role in these psychiatric conditions. Researchers

Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse noah cell.com/immunity/fullt…

How does Epstein- Barr virus induce multiple sclerosis? The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model) nature.com/articles/s4158…

Ana Falcão 's lab latest on multi-omics profiling of the Lateral Ventricle Choroid Plexus! ICVS biorxiv.org/content/10.110…