🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Congratulations🎉to Molecular Microbiology and Immunology at JHSPH Professor Sabra Klein Sabra Klein for being recognized as among the World's Most Highly Cited Researchers! The annual list recognizes researchers whose published papers rank in top 1% of citations for field & year👏 hub.jhu.edu/2022/11/15/joh…

Using a fluorescently labelled #Zika virion, we isolated ZIKV-reactive B cells. From our B cell cultures, we isolated an #IgM (DH1017) that mediated more potent neutralization than all our #IgG. 5/n

Our newly isolated DH1017 B cell line secreted these beautiful native hexameric and pentameric #IgM species. I was gratified to finally “see” the IgM I was working with! And it flutters!! 🤩 6/n

To ensure we were not dreaming🤨we put our #IgM 🟨 to the test and made a #recombinant #IgG 🔻with the SAME antigen binding sites. DH1017.IgM was 40-fold more potent than its IgG counterpart mAb at equimolar concentrations. Wow!😮 7/n

This is neat because our #immunology dogma is that IgM are weakly functional, but here we provide direct evidence of potent antiviral IgM function! 8/n

How did the IgM get so potent? With CryoEM we found the binding sites of DH1017 on #Zika virus. Computational modelling shows that the #IgM can bind the virion with multiple "arms" simultaneously. A novel approach for neutralization that is not feasible for #IgG. 10/n

Electron micrographs support this model - DH1017.IgM looks like a spider atop #Zika virus and captures the #Zika with multiple arms! 11/n

In this bent conformation, a theoretical maximum of three pentameric IgM can bind concurrently to the same virion, occupying 30 of the 90 epitopes present on the virion surface to #neutralize #Zika virus. 12/n

Also, DH1017.IgM can aggregate multiple #Zika virus particles, which would #neutralize by inhibiting virus uptake 13/n

We found that DH1017.IgM’s #ultrapotent function was better than potent anti-ZIKV IgG mAbs that were previously reported. So this IgM has the potential to be an effective candidate #therapeutic during #pregnancy! 14/n

Exciting finding by Dr. Singh Tulika Singh, PhD, MPH !

💪💔In Lviv, nine organ transplants from posthumous donors were performed without electricity. In 30 hours, the city's surgeons transplanted two hearts, a liver and six kidneys. Photo: МОЗ України

Wow -- the second most talked about JAMA article of the entire year was our paper. Also an Altmetric score near 10,000 is outlandish, COVID really changed the game. Jennifer Alejo, MD @martymakary @allanbmassie @teresachiangmd Amy Chang, MD Jonathan Mitchell

Congratulations to Sarah Frey Pisano !!!! So happy for you!!!

Congratulations to Caroline Qin !!!! I am so proud of you and Sarah Frey Pisano !! Wow congratulations!!

Congratulations yeahh!!

Ahh I didn't see your tweet then. Congratulations to you and Caroline Qin stars at The Transplant Research Center

Jennifer Motter et al show overall risk of invasive or skin cancers was not increased for HLA-incompatible LDKT recipients compared to compatible LDKT recipients. However, there was a possible elevation in colorectal cancer risk TransplantDirect Jennifer Motter doi.org/10.1097/TXD.00…

Summary: engaged US cohort of 💉💉💉 #transplant recipients reported 20% #COVID incidence & ~8% hosp. rate that ⬇️ 75% in contemporary #Omicron eras. Cases impressively spike with ⬆️US circulation; factor in risk counseling for frailest (most immunocompromised, lung, non-boosted)

The study by Motter et al. shows that risk of cancer after transplantation is NOT increased for Incompatible Living Donor #Kidney Transplant Recipients compared with compatible living donor kidney Tx recipients. #OpenAccess #MedTwitter #TransplantTwitter bit.ly/3Z18Ws3