Terry R Suk
@terryrsuk
Rousseaux Lab @uottawa studying TDP-43 dysregulation in ALS | @westernu Alumni | 🧠🧬
ID: 1050446799222296576
11-10-2018 18:03:28
178 Tweet
238 Followers
306 Following
Excited to share our work, new in Science Magazine: science.org/doi/10.1126/sc…. We explored how sex chromosomes, gonadal hormones, and their interaction shape cellular responses in aging and #Alzheimers mouse models. This led to key insights on Tlr7 and neurodegeneration 🧵(1/5)
Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in Nature Genetics with Towfique Raj Panos Roussos Friedman Brain Institute nature.com/articles/s4158…
Excited to share our latest Nature Medicine study from our new center Abrams Research Center on Neurogenomics! 🧠✨ Using spatial transcriptomics & scRNA-seq, we uncover how Aβ-targeting immunotherapies shape microglial responses in AD patient brains. A thread with our key findings is below! 🧵(1/15)
'A stress-dependent #TDP43 SUMOylation program preserves neuronal function' Terry R. Suk Terry R Suk Caroline E. Part, Jenny L. Zhang, Trina T. Nguyen...Maxime W. C. Rousseaux Maxime Rousseaux uOBMRI Université d'Ottawa | University of Ottawa #ALS …arneurodegeneration.biomedcentral.com/articles/10.11…
New Science Magazine Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective science.org/doi/10.1126/sc…
SUMO to the rescue! Three new studies show that tagging TDP-43 with SUMO2/3 keeps it soluble under stress, preventing the toxic aggregates that mark ALS and FTD. Université d'Ottawa | University of Ottawa, @UNIMORE_Univ, Goethe-Universität ow.ly/ROwi50VQk61