🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

🚨 We’re hiring! Científico Latino, Inc. is looking for a Program Director to lead two national STEM mentorship programs. Fully remote, impact-driven role in higher ed 🎓👩‍🔬 📌 Apply: cientificolatino.com/job 💼 Know someone? Send it their way!

Introducing FISHnet, a graph-theory-based method for sensitive and specific identification of chromatin domains from single-cell sequential Oligopaints data. nature.com/articles/s4159…

scTransient: Single-Cell Trajectory Inference for Detecting Transient Events in Biological Processes biorxiv.org/content/10.110…

New online! Cell-type deconvolution methods for spatial transcriptomics bit.ly/43hY2AT

Marsupial embryos lack the epigenetic reset seen in placental mammals nature.com/articles/d4158… #journals #feedly

Today in Science Magazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with Sternberg Lab. 1/13 drive.google.com/file/d/1I-UbCR…

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with Omer Ali Bayraktar , Oliver Stegle and Moritz Mall groups. Preprint at end🧵👇

Gene expression is controlled by regulatory sequences (promoters/enhancers) & transcription factors🧬 In theory, sequencing + epigenetic data should be enough to predict expression. This Sunday read reviews deep learning models trying to do exactly that👇

New online! Functional synonymous mutations and their evolutionary consequences bit.ly/43Dlee0

Science never follows a simple path from A to B, but we rarely publish the story of all the branches on the open ended paths we take to get to a result

If you're an international PhD student at Harvard working on something that my lab is familiar with and you're at risk of deportation, shoot me an email. We may be able to host you or find someone else who can.

Thrilled to see #SAVANA out in Nature Methods🥳 SAVANA detects haplotype-resolved somatic SVs and copy number aberrations (SCNAs) and infers tumour purity & ploidy in clinical samples using long-read sequencing with or WITHOUT a matched germline control 👇nature.com/articles/s4159…

Paper: science.org/doi/10.1126/sc… Explanation of the science: x.com/z_chiang/statu…

Predicting expression-altering promoter mutations with deep learning science.org/doi/10.1126/sc… 🧬🖥️🧪 github.com/Illumina/Promo…

EpiTrace infers cell mitotic age and evolution from single-cell ATAC-seq data go.nature.com/3QHBfc3 rdcu.be/em31W

REnformer: a single-cell ATAC-seq predicting model to investigate open chromatin sites biorxiv.org/content/10.110…

Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. nature.com/articles/s4159…

🎉 Excited to share our new publication in Cell Reports Medicine! 🙌 Big thanks to our amazing collaborators! 📄 lnkd.in/grHHDkKB #LiquidBiopsy #Oncosomes #EVresearch #RNASeq #CancerBiology #CellReportsMedicine

Our new preprint is live! doi.org/10.1101/2025.0… In collaboration with Sternberg Lab, we determined the cryo-EM structure of a dCas12f-σE-RNAP complex from F. taeanensis, revealing an RNA-guided transcription mechanism that bypasses canonical promoter motifs.