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Nature research paper: Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 go.nature.com/3Sq08Le

Pidathala, S., Liao, S., Dai, Y. et al. Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2. Nature (2023). doi.org/10.1038/s41586…

Structural Biology at St. Jude Children's Hospital is building a world class facility, this atomic resolution Krios G4 (with Cold-FEG+Falcon4+Selectris) is one of the best setups in the US! Come see what the future of Structural Biology looks like at St Jude!!! ♥️

Online Now: Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals dlvr.it/T7FMQW

It is great fun to collaborate with Matthew Freeman, now only @mjafreeman.bsky.social, the leading expert in the field. Fangfang Lu and Hongtu Zhao worked together to reveal the structures of the ADAM17 sheddase complex and showed how iRhom2 restrains ADAM17 protease activity. sciencedirect.com/science/articl…

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals dlvr.it/T7yTN0

Recovering true FRET efficiencies from smFRET investigations requires triplet state mitigation pubmed.ncbi.nlm.nih.gov/38877317/ Grateful for the rigorous and tireless efforts from all authors of this work. Thankful to the Editor and Referees for helping us refine the take home messages!

Excited to share our Annual Reviews in Biophysics article on Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function. Many thanks to all authors for their diligence putting this summary overview together! pubmed.ncbi.nlm.nih.gov/39013028/

Recovering true FRET efficiencies from single-molecule FRET experiments requires triplet state mitigation: rdcu.be/dOv3q. Donor and acceptor fluorophores accumulate in triplet states with elevated illumination intensity, which can effect FRET efficiency if unmitigated.

Transport mechanism and structural pharmacology of human urate transporter URAT1 | Cell Res doi.org/10.1038/s41422…

Beautiful work from Chia-Hsueh Lee, just out in Cell Research #CryoEM structures of human URAT1 provide insights into urate recognition, transport mechanism, and MOA of anti-gout drugs. #OpenAccess nature.com/articles/s4142…

Researchers uncovered ten unique structures of URAT1, providing a deeper understanding on the urate transport mechanism that may offer insights into kidney disease mutations and help guide therapeutic design for gout. Learn more: ow.ly/TKS950Tjxhb

Is it substrate? In our preprint led by Biao Qiu, we comprehensively assess EAAT3 substrate recognition properties using DSF, SSM ephys, and cryoEM. The L-Cys bound structure suggests that sodium binding is the final step of gate closure. Read below! biorxiv.org/content/10.110…

Human URAT1 transports urate and is a target for gout treatment. The Lee lab @stjuderesearch presents 10 cryoEM structures of URAT1 with urate, pyrazinoate, and 3 anti-gout drugs, providing mechanistic insights into urate recognition, transport cycle, and inhibition by drugs.

Congrats! Scott Scott C Blanchard

Congrats!!! TanjaMittag

As 2024 ends, we’re celebrating key discoveries by St. Jude scientists. In this #ResearchWrapUp, we’re highlighting advances in #MolecularBiology that connect basic science to better health.

Membrane Transport subgroup Biophysical Society is thrilled to announce the Chris Miller Award—honoring groundbreaking contributions to membrane transport—debuting at the BPS Meeting! Named for Chris Miller, a true pioneer & mentor. Awardees will lecture at our subgroup symposium.