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We are delighted to share our work, now available in nature: nature.com/articles/s4158… Our scoring system can be accessed here: kinase-library.phosphosite.org Coming soon --> the tyrosine kinome and an improved system with many new functionalities & features! #TheKinaseLibrary #KL

Nuclei of wild type (Htt-25Q) and mutant (Htt-94Q) live mouse ES cells. The mutation associated with Huntington’s disease produces the large and stable protein aggregates seen at right by super-resolution single molecule tracking. #FluorescenceFriday #cellbiology #neuroscience

In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to self-organize embryonic stem cells into spatially-ordered embryonic patterns. biorxiv.org/content/10.110… #crispr

Stem cell colonies from PertzLab 🤝 interactive data visualisation in napari. Segmentation, tracking, single cell signalling states... So much fun to explore and search for patterns this way

A comprehensive single-cell breast tumor atlas defines epithelial and immune heterogeneity and interactions predicting anti-PD-1 therapy response (includes six new NK cell subsets) Cell Reports Medicine Isaac Chan, MD, PhD cell.com/cell-reports-m…

It's really hard to build brand new discovery technologies *and* a world-class therapeutics pipeline at the same time. What are potential strategies for companies that think most of their platform value is in the future? A thread with some thoughts:

Fascinating work, has been awesome to see this story develop. Congrats Isaac Chan, MD, PhD and team!

new results! We describe an optogenetic method to 'paint' patterns of morphogen signals in zebrafish embryos to guide their development. Preprint here: biorxiv.org/content/10.110… Check out Nathan Lord's explainer thread for the details!

2/ #FluorescenceFriday #cellbiology #bioart Dictyostelia start out as unicellular amoeba, but eventually many amoebae come together to form a multicellular slug and, eventually, a fruiting body to complete its life cycle. The initial stages of aggregation are shown here in 3D at

Tim Aikin and Adler Guerrero Zuniga work is out in Developmental Cell! You guys are amazing. If you are interested in how oncogenes can prime cells for whole genome doubling take a look! authors.elsevier.com/a/1iy3F5Sx5gxk…

Capturing the axial elongation of a zebrafish embryo (back and forth) using our single objective LSM DaXi #FluorescenceFriday #zebrahub #zebrafish 🐟🔬

LLMs have proven useful for increasing sequence diversity while maintaining properties and structure, such as binding of antibodies and peptides. Here Jeff Ruffolo and Profluent team demonstrate enzyme sequence diversification while maintaining editing functions. Nice work!

We joined forces with ARCH Venture Partners / Robert Nelsen to incubate XairaTherapeutics, a biotech company using AI to re-engineer the entire drug discovery and development process. Read more: endpts.com/in-biggest-eve…

Connor's paper is out in Science! Thanks to all the present and former lab members for making this possible. If you are interested in the mechanisms behind stress induced endocycling or the role of CDK4/6 in maintaining G2 arrest, check it out: science.org/doi/10.1126/sc…

We are delighted to share the #tyrosine The Kinase Library, now in nature: nature.com/articles/s4158… Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org #TheKinaseLibrary #KL #part2 🧵 1/9

I remember the first time I heard about this effort from Sergi Regot Very excited to dive into this for two reasons - identification of orphan kinase substrates (new pathways) and development of new synbio tools for kinase signaling. Great work!

We’re excited to share our study in Cell on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. cell.com/cell/fulltext/…

Protein design for ...checks notes... growing semiconductors (!!) Biology is nanotechnology.

Astonishing breakthrough in #organoid engineering, as reported in nature by T Recaldin,M Harter,L Steinacher,B Gjeta, and colleagues: intestinal epithelial organoids incorporating tissue-resident immune cells. Institute of Human Biology Roche go.roche.com/4a5t1

What does pushing the boundaries of model capacity and data scale do for generative protein language models? I’m super excited to share our latest work Profluent where we begin to explore and test some of our hypotheses!