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A review of progress in cell replacement therapies for #T1D #diabetes #stemcells #islets Nature Reviews Endocrinology nature.com/articles/s4157…

The latest HIRN Newsletter is available online! Information about our upcoming meeting, new publications, meetings and funding opportunities! View at: conta.cc/3Xi2D2

AnnoSpat annotates cell types & quantifies cellular arrangements from spatial proteomics ft. Aanchal Mongia, Noah Burget, Yeqiao Zhou 周叶峤, R. Babak Faryabi (Penn Path & Lab Medicine/ Penn Epigenetics), Yue Wang, @KlausKaestner & Golnaz Vahedi (Penn Genetics) & Ali Naji (Penn IDOM) tinyurl.com/3ffj3rey

We welcome investigators to submit their abstracts to present orally or at our poster session during the 17th Annual Scientific Meeting! Deadline is November 18th at 5PM: npod.org/abstracts

Don't wait - register now for the 2025 HIRN Annual Meeting to learn & discuss the state of the diabetes research & future direction of T1D research. Preliminary agenda posted on the website. Register at: niddk.nih.gov/news/meetings-…… All welcome to attend! Please share

Yi and Eizirik re‐analyzed scRNA‐seq data from The Human Pancreas Analysis Program - HPAP database to further investigate the β‐cell stress signatures (e.g, inflammation, autophagy, apoptosis, and ER stress) potentially present in individuals living with #type1diabetes and #type2diabetes. onlinelibrary.wiley.com/doi/10.1111/17…

This Thursday 12/12 come join us for Carmella Evans-Molina Dr. Carmella EvansMolina on ER regulation of beta cell function!

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells ft. Varun Bahl, Eric Waite @CatherineLeeMay Elisabetta Manduchi, Benjamin Voight Michelle Lee Mark Tigue, Nicholas Manuto & @KlausKaestner (Penn IDOM/ Penn Genetics) science.org/doi/10.1126/sc…

Looking forward to a great PANC-DB demo at the HIRN meeting!

*Job Alert* The Integrative Immunology and Cell Design Laboratory led by Dr. Mo Haj Dezfulian at the University of Pennsylvania is recruiting postdoctoral fellows! For more information: med.upenn.edu/apps/my/index.…

Please check out the new preprint from HPAP: Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas biorxiv.org/content/10.110…

The January/February Issue of the HIRN newsletter is available online. Information about a recent The Human Pancreas Analysis Program - HPAP publication, PanKbase launch, meetings/webinars and job postings! View at: conta.cc/4idBgjj

HPAP recently added 49 new single-cell multiome data sets to PANC-DB! Access the data here: hpap.pmacs.upenn.edu

The new interactive HPAP perifusion data dashboard is now live on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/perifu…

In the new series by Diabetes Care highlighting 75 years of NIH NIDDK research, the groundbreaking TEDDY Study is featured. This pioneering study is helping better understand the environmental determinants of Type 1 Diabetes in youth and includes UFDI faculty investigators — Dr.

Two new, NIH funded postdoc positions are available! (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans - please send CV and names of references to: [email protected]

🚨New work from our lab with important clinical implications. Thanks to our collaborators in ⁦The Human Pancreas Analysis Program - HPAP⁩. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv biorxiv.org/content/10.110…

New research published in Nature Communications with UFDI collaborators Dr. Melanie Shapiro, Dr. Mark Atkinson, and Dr. Todd Brusko reveals immune cell disruptions in pancreatic lymphatic tissues may precede Type 1 Diabetes onset—offering key insights into early detection and

Please check out our HIRN webinar “Introduction to the New Islet Function Portal on PANC-DB" here: youtube.com/watch?v=UdcauF…

HPAP now has CODEX data available from 148 donors on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/downlo…