June #TopRead from UAlberta Med & Dent and Women & Children's Health Research Institute found distinct gene expression profiles in CD71+ erythroid cells at various developmental stages, suggesting a critical role for Gal-3 in modulating erythropoiesis and enhancing immunoregulation. Read more: ow.ly/L8uv50WiiFm

Researchers have described key events in the pulmonary anti-Influenza A (IAV) response of pigs, which open new avenues for developing IAV vaccines and therapies, and enable the better use of pigs as a model for human IAV infection and immunity. Learn more: ow.ly/xjnl50WlNLa

Data suggest that the NLRP3 inflammasome engages an additional innate immune lytic cell death pathway, PANoptosis, for cell death beyond the early timepoints of innate immune responses, which may lead to new therapeutic targets. Learn more: ow.ly/ZkJy50WlNT1.

In a #CuttingEdge article, researchers identified an in-del generated novel neoepitope that elicited in vivo tumor control in models of prophylaxis and therapy. CD8 T cells elicited by this neoepitope showed notably less exhaustion. Learn more: ow.ly/IVtu50WlKRA.

The June cover image is from @Naglaa_Shoukry at Centre de recherche du CHUM and their work demonstrating that treating mice with the RORγt inhibitors improved the appearance and function of the liver during #LiverFibrosis. Learn more: ow.ly/v1Tp50Wslwv

The July issue of The Journal of Immunology is online now! Including a special collection on human and #clinical immunology, this issue of The JI is full of exciting new research and reviews. Read the full issue online: ow.ly/bfEp50WuPGk.

This #BriefReview focuses on interferon (IFN) production in the thymus and its effects on thymic antigen presenting cells and developing thymocytes examining the importance of T-cell tolerance to IFN and interferon-stimulated proteins. Read more: ow.ly/53zc50WuPIL.

In their editorial for the special collection “Human and Clinical Immunology: An Evolving Landscape,” Dr. Roshini Abraham and Dr. Gerald Morris discuss the current pivotal moment of clinical immunology and the benefits of publishing in #TheJI. Read more: ow.ly/xB4Y50Wzn4Y

A #BriefReview in the Human and Clinical Immunology Special collection discusses natural killer cells as an emerging tool for cancer #immunotherapy due to their innate ability to selectively recognize and eliminate cancer cells. Read more in The JI: ow.ly/B5eN50Wzsku.

Researchers engineered Ab5, a germline-like anti-human epidermal growth factor receptor 2 monoclonal antibody, and enhanced its antibody-dependent cellular cytotoxicity properties through affinity maturation showing notable enhancement of tumor ablation. ow.ly/QOo150WCLlX.

New data point to a unique role for Ly49C/I in adaptive NK cell antigen recognition and provide further insight into the mechanism behind adaptive NK cell responses. Ly49G did not appear to play any role in NK cell memory responses. Learn more: ow.ly/hPiR50WHbRP.

Five computationally optimized broadly reactive antigens (COBRAs) were designed from influenza A H3N2 viruses that circulated 2018-2022 and showed improved protective efficacy in vaccinated mice and ferrets. Read more: ow.ly/y22c50WHbSf.

Data revealed B cell-dependent CD1d expression is critical for the effectiveness of a potent lipid-based adjuvant in augmenting polysaccharide and phosphorylcholine-specific IgG responses, which could help improve #vaccines. Learn more: ow.ly/NG6h50WHbSM.

Last call for peer-review mentor and mentee applications! The AAI Peer-Review mentorship application window closes August 31. Don’t miss out on your chance to contribute to the future of peer-review literature in The JI and ImmunoHorizons. Apply today: ow.ly/PWuJ50WCLqm.

The August issue of The JI is available now! Including a collection of immunoparasitology reviews, this issue is full of research and reviews from esteemed colleagues. Read the full issue online today: ow.ly/uGxR50WOgHO.

Antibacterial agents for Gram-negative infections are struggling to meet clinical demand. Researchers presented a novel #immunotherapy with the ability to harness endogenous anti-αGal antibodies for the clearance of Gram-negative #bacteria. Learn more: ow.ly/qXbp50WOgRM.

Data suggest that exhaustion markers contribute to the hyporesponsive profile of lepromatous patients. PD-1 blockade could contribute to the reestablishment of lymphocyte effector action and possibly be incorporated into multidrug therapy for leprosy. ow.ly/Esoj50WOgWm.

Data suggest IFN-β counteracts the harmful impacts of α-CD20 on respiratory viral infections, offering potential anti-viral strategies for patients with autoimmune diseases whose immune function may be impacted by disease-modifying therapies. See more: ow.ly/fmzW50WOgzr.

TCRγδ+ T cells are a major lymphocyte population of chickens, but their role in avian influenza virus (AIV) immunity was unclear. Data revealed that strong TCRγδ+CD8α+T cell response is critical in protecting chicken against H9N2 AIV infection. See more: ow.ly/Uq7n50WOgEC.

In a #TopRead from August, Waggoner Lab from Cincinnati Children’s Research discovered that the transcription factor ASCL2 is required for recruitment of NK cells into the spleen and white pulp providing novel insights into NK cell biology. Read more: ow.ly/NSx150WTnSr