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It is a fascinating study in the shift of semantic range that the term “chemotherapy”, both in professional and lay speech, is now used almost exclusively to refer to cytotoxic chemotherapy for cancer rather than its original, broader meaning.

Just wrapped data extraction for our global vaccine RCT review: 260 trials (1951 to 2025) 2,468,751 trial participants Possibly the most comprehensive dataset of its kind. Huge thanks to the team that powered through to this milestone. Brad Spellberg docs.google.com/spreadsheets/d…

Unbelievable opus magnus on randomized controlled trials of vaccines. Website is updated to 260 trials and close to 2.5 million patients randomized. We will put a peer reviewed manuscript together on this. bradspellberg.com/vaccine-rcts

Thank you! This was a huge team effort, with amazing collaborators and anonymous contributors around the world working late into the night. Grateful to everyone who made it possible. Brad Spellberg Abhay Dhand Neal Fox Alejandro Diaz Alí Sebastian Meza Dr. Adam Lauring Jeff Keelan

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The work has been deeply collaborative. The idea to crowdsource controlled vaccine trials came from Brad Spellberg, and we've had a phenomenal team - Alí Sebastian Meza, Abhay Dhand, Neal Fox, Alejandro Diaz, and help from many contributors from around the world. bradspellberg.com/vaccine-rcts

Loud claims are circulating that “no childhood vaccine was ever tested against placebo.” That is flat-out wrong. Here’s what the evidence actually shows. 🧵👇 1/

Public trust in vaccines is built on facts, honest & transparent communication, and steady expertise. Replacing ACIP’s scientists with outspoken skeptics does the opposite. I explain why in my new STAT op-ed: statnews.com/2025/06/11/rfk…

RFK Jr. went on national TV and spouted egregious, dangerous falsehoods about vaccines. As a parent and infectious diseases doctor, I couldn't stay silent. Fox News might not fact-check him, but I will. I've reviewed the trials. I've catalogued them. I have receipts. 🧵

For further details re this statement by RFK Jr, “We’ve gone up from 11 vaccines in 1986. Today, children get between 69 and 92 vaccines before they’re 18." The 1986 childhood schedule: DTP x 5 OPV (oral polio) x 4 MMR x 1 = 10 injections + 4 oral doses Today’s routine

It’s understandable to have questions about aluminum in vaccines. Here are the key facts: 🧵

I enjoyed this book enough to argue that it should be required reading. It’s actually easy to digest and very informative. Educate yourself!

Playing VÆmpiric 🦇- An Antibiotic Card Game with IM residents in ICU today

I've been hearing a lot about this common concern: "Are kids getting too many vaccines?" It's a fair question. I'm a parent too. And as an infectious diseases physician who directs an antibiotic stewardship program, a big part of my job is stopping unnecessary medications. I'm

The 17 fired members of ACIP, including me, have written an article in JAMA about our experience and our concerns. jamanetwork.com/journals/jama/…

Educating pharmacy residents and student pharmacists, along with medical residents and students each day, is one of the greatest pleasures of my career! We truly learn together every day! We Teach. Premier Health

The aluminum question: why the route of exposure matters less than you might think Aluminum in vaccines worries a lot of people. The word sounds industrial, not medical. I get that. Yet aluminum-based adjuvants have been part of routine immunization for over 90 years, and the

Really grateful CIDRAP covered our volunteer project reviewing vaccine RCTs. We're up to 335 trials with >5.8 M participants and counting. "Essentially every childhood vaccine has been tested in placebo-controlled trials of some sort." Brad Spellberg cidrap.umn.edu/adult-non-flu-…

THREAD: With measles resurging (>1,100 U.S. cases in 2025 so far, CDC week 23 update) and RFK Jr.'s panel set to revisit thimerosal next week, many are asking again: do vaccines cause autism? Bottom line: no. As a parent, I recognize how high the stakes feel when making

Routine vaccines cut U.S. cases of once-common diseases by 95%-100% - and deaths to virtually zero. Let's not go backwards. Sources: stacks.cdc.gov/view/cdc/175682 pubmed.ncbi.nlm.nih.gov/18000199/