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Our latest: 'Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis' Brain Link: academic.oup.com/brain/advance-… Well done Doaa M Taha Ben Clarke Collab with TheSibleyLab Thanks:Medical Research Council MND Research UCL Queen Square Institute of Neurology The Crick

.PataniLab and TheSibleyLab researchers, led by Doaa Taha (Doaa M Taha) at the University College London (UCL Queen Square Institute of Neurology) show that VCP mutant #astrocytes 🧠 undergo cell-autonomous reactive transformation seen by increased expression of complement C3. 🔬 bit.ly/3ryaVUr

We’re advertising an exciting post-doc The University of Edinburgh integrating #scRNAseq & #hIPSC motor neurons to screen for novel small molecules targeting #MND. Come join us in this amazing city & great research centre. Apply by 10.6.22: bit.ly/3NAcqel Edinburgh Neuroscience Biological Sciences | University of Edinburgh

1/3 Very excited to announce that our collaborative research from GregoryLab, TheSibleyLab, Olivia Rifai on inflammatory drivers in #MND #ALS has been funded by an MND Scotland Research Award @aberdeensmmsn mndscotland.org.uk

Last few days to go.... please RT

Such a well-deserved award. It is always such a privilege to work with Mathew H Horrocks and we are delighted that his hard work has been recognised with this award. Congratulations 🥳👏🏻

Just re-plugging the #postdocjobs available in my lab at UCL in London to uncover roles for nascent #RNA in the regulation of #polycomb and other #chromatin modifiers. Funding also now in place for 3 years! Deadline June 20th.

We’re advertising an exciting post-doc The University of Edinburgh integrating #scRNAseq & #hIPSC motor neurons to screen for novel small molecules targeting #MND. Come join us in this amazing city & great research centre. Apply by 1.9.22: bit.ly/3wvYeN5 Edinburgh Neuroscience Biological Sciences | University of Edinburgh

Great first lab retreat at the Free Company in Balerno yesterday!

Our digital pathology study profiling glial activation and protein misfolding in a heterogenous cohort of C9-ALS post-mortem tissue is out in Journal of Pathology! 🧵 GregoryLab TheSibleyLab onlinelibrary.wiley.com/doi/10.1002/pa…

Take a look at our recent work implementing machine learning & digital pathology in ALS post mortem tissue. Lots of interesting findings using this approach - my fav - we identified FUS pathology in C9orf72-ALS cases #DigitalPathology #ALS #CureMND

A Postdoc position available in our lab MRC_HGU to study DExH/D RNA helicases and GPATCH proteins in pre-mRNA splicing with relevance to Colorectal cancer (CRC), in collaboration with Malcolm Dunlop elxw.fa.em3.oraclecloud.com/hcmUI/Candidat… Application deadline, 21st February 2023

(1/3) Preprint showing our molecular analysis of a cohort of ALS post-mortem tissue, identifying two distinct inflammatory signatures Olivia Rifai Fergal Waldron TheSibleyLab Prof Jenna Gregory @pichaelmichael_

Our pre-print profiling neuroinflammation in ALS is now online at bioRxiv Neuroscience! We identified 2 distinct neuroinflammatory signatures that exist across C9, SOD1 and sporadic ALS cohorts GregoryLab TheSibleyLab #ALS #C9orf72 #SOD1 #inflammation (1/9) biorxiv.org/content/10.110…

Great opening session of #ADPD2023 congratulations to Olivia Rifai for winning a prestigious junior faculty award for her work on the role of neuroinflammation in ALS

Congratulations Olivia Rifai, what an amazing and well deserved award!

🚨🧐Job alert!!! we are looking for a postdoctoral researcher interested in #RNA biology and #cancer, to investigate RNA misprocessing in high-grade #gliomas and develop RNA-targeting therapies. Please RT and DM me if interested @Biodonostia Ikerbasque

We had an amazing time discussing great science and enjoying the mediterranean sun in #ENCALS2023 #ALS #ELA #cureALS

The advance article for our study identifying 2 distinct neuroinflammatory signatures that span across C9-ALS, sporadic ALS and SOD1-ALS post-mortem tissue cohorts is now open access in Brain! GregoryLab TheSibleyLab academic.oup.com/brain/advance-… (1/8)

Rifai et al. characterise neuroinflammation in brain tissue from patients with ALS and identify two distinct inflammatory signatures, which do not appear to segregate with genetics or clinical symptoms. tinyurl.com/yes9jb7h