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We have a new paper to show how multiple condensin molecular motors create the mitotic chromosome structure.

Our research was featured on the cover of the current issue of Cell Reports. The picture is an artistic interpretation of how mitotic #chromosomes are built by #condensin molecules. Made in Blender 🔶 using the #molecularnodes package developed by Brady Johnston.

New preprint from our lab

We are happy to share our recent work on PNASNews (pnas.org/doi/10.1073/pn…). Thanks to Dave Thirumalai, Hung Nguyen, Naoto Hori and Thirumalai Lab @ UT Austin . We established a link between the folding landscapes of the monomers of CAG repeats RNA and their propensity to self-associate.

We introduce a new sequence-specific force-field (christened as COFFEE) for simulations of DNA-protein complexes. COFFEE reproduces many experimental results (SAXS, NMR), and accurately describes the nuances of nucleosome dynamics.Thirumalai Lab @ UT Austin biorxiv.org/content/10.110…

Wondering how glycans affect the ACE2-RBD binding in SARS-CoV-2 infection? Our new Thirumalai Lab @ UT Austin paper in Biophysical Journal highlights that the interactions of glycans in ACE2 receptors are largely entropic rather than enthalpic! Check out more here ➡️ authors.elsevier.com/a/1h7lh1SPT42Q8

Congratulations to Debayan Chakraborty for his position at IMSC chennai as an assistant professor. Dr. Chakraborty will be joining later this month. We wish him a succesful independent career, and stay tuned for exciting biophysics coming from his lab.

Congratulations Dr. Davin Jeong for successfully defending her PhD!! Davin Jeong studied interphase chromosome structures with MD simulations and data-driven methods. Read up on her work here biorxiv.org/content/10.110…

We had a farewell party for Hung Nguyen who starts his independent career at UB Dept of Chemistry. Best wishes for Hung and his future!

Hi-C, or genome-wide chromosome conformation capture, experiments report the interaction probabilities of arbitrary locations on genomes. Using Hi-C data, this #PRXLife study crafts a polymer parameter-free model that reproduces chromatin structures. 📝 : go.aps.org/3KJO7eU

#ICYMI: researchers extracted interaction energies from genome-wide chromosome conformation capture experiment data and developed a model that shows how the disparity in these energies explains compartment formation in conventional and inverted nuclei. 📝 go.aps.org/3KJO7eU

We are excited to share that our recent work on understanding the unusual dependence of viscosity on cell packing fraction observed in an experiment has been published in eLife. More details are in the following thread.Thirumalai Lab @ UT Austin Xin Li doi.org/10.7554/eLife.…

Check out our new paper here.. tinyurl.com/5n63zk74

Free volume theory explains the unusual behaviour of viscosity in a non-confluent tissue during morphogenesis. elifesciences.org/articles/87966…

In eLife - the journal: Structural basis for the preservation of a subset of topologically associating domains in interphase chromosomes upon cohesin depletion doi.org/10.7554/eLife.…. #3Dgenome. Another eLife paper from Thirumalai Lab @ UT Austin Davin Jeong @anyuzx.

Very excited to share the preprint on the computational study of protein aggregates :) We questioned the various morphologies and dynamics of protein aggregates found in experiments. Our study shows the entropy of the sequence and rigidity matters! biorxiv.org/content/10.110…

Excited to share our new paper: "Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos" with Thirumalai Lab @ UT Austin, @Jbwallingford, Mark Peifer, Margot Kossmann Williams, Jessica, Robert J. Huebner. Read it here: biorxiv.org/content/10.110…. #devbiol #nematic

RT plz! APS Focus Session "Genome Organization & Subnuclear Phenomena" is coming back at the 2025 Global Physics Summit! We invite the abstracts of latest developments in the 4D genome using experimental, theoretical, and/or computational methods, from all-level scientists! [1/4]

Last call: the APS abstract submission is due 5pm EDT today! Don't forget to submit your abstract if you haven't done yet! Our session is a nice inclusive mixture of experimentalists and theoretical/computational scientists at all levels, so please come and join us!

My study on glycan-glycan interactions is now published in J. Am. Chem. Soc.! We found that uncharged N-glycans show long-range pair repulsion, which varies logarithmically (⬅️unexpected analogy w/ star polymers!). We highlighted the role of water in the repulsion. pubs.acs.org/doi/10.1021/ja…