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The extent of extra-valvular cardiac damage before and after TAVR and changes in cardiac damage early after TAVR have important implications during long-term follow-up. authors.elsevier.com/a/1izXK6uPJvuU… Masaaki Nakase; Daijiro Tomii; Fabien Praz; Stefan Stortecky

Prediction of the Individual Aortic Stenosis Progression Rate and its Association With Clinical Outcomes jacc.org/doi/10.1016/j.…

Cardiac damage staging in aortic stenosis is ready for prime time. Excellent Editorial by Philippe Pibarot. sciencedirect.com/science/articl… Masaaki Nakase Daijiro Tomii Fabien Praz

Medical News in Brief: Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities ja.ma/3wcCoBn

Patterns of cardiac damage secondary to aortic stenosis differ by sex. Female sex was an independent predictor of lower mortality in early stages, but not in advanced stages of upstream cardiac damage. authors.elsevier.com/sd/article/S19… Masaaki Nakase Daijiro Tomii Fabien Praz Annette Maznyczka

VARC-3 periprocedural myocardial injury was associated with a 2-fold increased risk of CV death at 1 year after TAVR. The favorable association of RAS inhibitor prescription was consistent in patients with and without periprocedural myocardial injury. authors.elsevier.com/sd/article/S27…

Asymmetrical expansion of balloon-expandable THVs, manifesting as stent frame deformation, is an occasional fluoroscopic finding in TAVR and has been associated with impaired hemodynamic valve performance in a registry of 1216 patients. authors.elsevier.com/sd/article/S19…

Prolongation of the QT interval is a manifestation of delayed cardiac repolarization. In the SUMMIT study, QTc became gradually longer along the climb from base camp to the summit of Mount Everest, and 1 in 4 climbers developed acquired long QT syndrome. authors.elsevier.com/sd/article/S24…

When it comes to transfemoral access for TAVR it is all about diameter, calcification and tortuosity. In the Bern TAVI registry, the Hostile score proved useful in predicting non-puncture site vascular complications after TAVR. authors.elsevier.com/sd/article/S19…

morning run #TCT2024

The inflammatory pathway offers a potential therapeutic target in patients undergoing TAVR: in the Co-STAR trial treatment with colchicine was associated with a lower risk of cardiac arrhythmias and subclinical leaflet thrombosis at 30 days. #TCT2024

Timing of intervention in patients with aortic stenosis. authors.elsevier.com/sd/article/S19…

Fibrotic versus calcific aortic stenosis in patients undergoing TAVR. authors.elsevier.com/a/1k83T6uPJvuW… Annette Maznyczka Domenico Angellotti Daijiro Tomii Christoph Gräni Daryoush Samim Pernille Bække Stefan Stortecky

TAVI in patients with bicuspid aortic stenosis: navigating anatomical challenges and tackling a cocktail of risks jacc.org/doi/10.1016/j.… Annette Maznyczka

Echo screening of TB patients facilitates early detection of CV involvement. Routine echo at baseline in all newly diagnosed TB patients may allow for timely medical management and prevent complications such as constriction and heart failure. JACC Journals sciencedirect.com/science/articl…

Aortic Stenosis and Coronary Artery Disease: Decision-Making Between Surgical and Transcatheter Management doi.org/10.1161/CIRCUL… Daijiro Tomii

In the Bern TAVI registry, hemodynamic valve deterioration occurred in up to 1 in 4 patients throughout 10 years post-TAVI and was associated with a 5-fold increased risk of aortic valve reintervention. #JACCINT authors.elsevier.com/sd/article/S19… Bashir Alaour Fabien Praz Stefan Stortecky

CIDRZ and the University of Bern are teaming up to fight #RheumaticHeartDisease (RHD) in Lusaka! A study targeting children aged 5–16 in 12 schools will assess the effectiveness of a school-based programme in preventing RHD in high-prevalence areas.

In the SCOPE I trial, patients with frailty had a similar improvement in patient-reported health status measures after TAVR, but a higher risk of unfavorable outcomes throughout 3 years of follow-up. authors.elsevier.com/sd/article/S27…

Non-coaxial transcatheter aortic valve deployment relative to the native annulus is associated with impaired valve early safety and increased risk of bioprosthetic valve failure 1 year after TAVR. jacc.org/doi/10.1016/j.…