
Thue W Schwartz
@thue_schwartz
#GPCR Aficionado - #Metabolite_Sensing & Signaling in #Endocrine and Metabolic Tissues and #Cancer / Structure-based #Drug_Discovery/#Innovation @MetabolCenter
ID: 1404835036432568323
https://cbmr.ku.dk/research/nutrient-and-metabolite-sensing/schwartz-group/ 15-06-2021 16:17:06
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Fantastic SUND Innovation day - particularly proud to see young NNF Center for Basic Metabolic Research (CBMR) scientists Rike Frederike Sass and Jonas Jonas Odgaard Petersen both winn prestigious UCPH innovation award. The Centers torch: āGreat basic research leads to innovationā is carried on by a āthird generationā


Looks like a great Symposium and talk at Karolinska Institutet - Zach Gerhart-Hines you could change #Diabetes treatement totally through the avenue you have EMBARKed upon at NNF Center for Basic Metabolic Research (CBMR) hitting insulin sensitivity, appetite and energy expenditure through one strike/ a single target!


One week ago, Professor Thue W Schwartz had an audience with HM the Queen after he was awarded the UCPH Innovation Prize. š If thereās someone who understands the innovation mindset, itās Thue! A founding member of CBMR, Professor Thue Schwartz is a pioneering fundamental


Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Idaš. I'll post more later, but for now here is a link: nature.com/articles/s4158⦠and a short movie about the work

So Proud of you Asli - such a cool story revealed by MD, Metadynamics and mutagenesis - pharmacology is determined by MOVING molecules. Now being used in your innovative Drug Discovery at NNF Center for Basic Metabolic Research (CBMR)



Congratulations Christoffer Clemmensen with your first ā but far from last - seniorauthor paper in āthe real' nature. This actually matters - in particular when it deals with solid, oldfashioned, real science ā and not just another sexy, topical story. Looking forward to your next one.


An- as usual - fantastic The Brain Prize event 2024 with HM King Frederik and Oh Land - both in great form. This year honoring Theoretical and Computational Neuroscienctists Larry Abbot, Haim Sompolinsky & Terrence Sejnowski - Great Choices. Thanks to Lundbeckfonden


Great Work from three truely competent senior authors and their labs. The elusive, double edged physiology and pharmacology of GIP may finally start to be understood from this deep analysis of receptor mutants. Genetics meets receptology. Read Alexander S. Hauser 's great thread


Amazing puzzle of 30 (thirty) HCAR2 structures when pieced together by @A_Shenol show the complex binding path/ agoPAM control of dynamic entry gate/ and two-way allostery with G protein. Read Asliās thread below and her true MD story in Molecular Cell: doi.org/10.1016/j.molcā¦


#METABOLITE #GPCR sensing - How #ketones (beta-hydroxybuturate), monomethylfumarate (MS drug), and #niacin works. Great editorial process at Nature Communications thanks. NNF Center for Basic Metabolic Research (CBMR)



Truely Fantastic work by Zach Gerhart-Hines and your NNF Center for Basic Metabolic Research (CBMR) and Embark Biotech teams over almost 10 years to identify our old NK2R as a cardiometabolic target to hit 1) energy expenditure 2) food intake and - importantly - 3) insulin sensitivity. So Proud. Move over #wegovy.
