Congrats to Honggui Wu Jiankun Zhang Longzhi Tan. By achieving the highest resolution of single-cell 3D genome structures (5kb) with scMicro-C, we proved the involvement of cohesin-mediated loop extrusion in human transcription, for the important function of fast reinitiation.

Computational methods for analysing multiscale 3D genome organization go.nature.com/3Lhb4Xb #Review by Yang Zhang, Lorenzo Boninsegna, Muyu "Wendy" Yang, @NCITomMisteli, Frank Alber & Jian Ma 4DNucleome Ray and Stephanie Lane Computational Biology Dept. CMU School of Computer Science UCLA UCLA QCBio National Cancer Institute

Hello 3D genome people! Did you know that C. elegans has a good looking cohesin but no CTCF? The newly graduated Dr. Jun Kim Jun Kim decided to look at what cohesin does for the compact, 100 Mb worm genome, fitting ~20,000 genes: biorxiv.org/content/10.110…

Don't miss our fantastic "3D nuclear topology in cancer" virtual Symposium coming this November. We are lucky to have a number of prominent figures in the field presenting brand new work! Organized by Jane Skok Melnick Lab ...NYU GSOM Pathology NYU Grossman School of Medicine & Weill Cornell Medicine

The new paper "Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries" from Eric Joyce is now available on Nature Communications. nature.com/articles/s4146… #4dnucleome

Very lucky to be part of it, thanks to all the supports from my wonderful colleagues!

... and now it's real! 🤗 Out now Nature Communications!! Incredibly happy to see this work published and very proud of my team! #Enhancer #3Dgenome #Glioblastoma #CancerNeuroscience nature.com/articles/s4146…

Principal theories of cancer origins

Interested in systems biology, gene expression, chromatin, genome structure, AI & deep learning? Please join us - Stirling Churchman, Sara Mostafavi, Alistair Boettiger and all amazing speakers) - on March 13-16 2024 at CSHL (NY, US): meetings.cshl.edu/meetings.aspx?… (please RT)

Sharing our recent review Molecular Cell discussing the current understanding of the essential role of RNA Pol II elongation in gene expression & its role in human disease & aging. Northwestern BMG and SQE Cell Northwestern Feinberg School of Medicine bit.ly/3Mtaczc Video: youtu.be/r0XjjmGIz2M

Check out the upcoming Cold Spring Harbor meeting on Genome Organization & Nuclear Function, Apr 20 – May 4, 2024, on advances in spatial and temporal aspects of nuclear structure & function. We look forward to seeing you! Wickstrom-Lab Jane Skok Andrew Belmont CSHL Meetings

Latest #CDlab paper online now in Science Magazine: science.org/doi/epdf/10.11… In this important hypothesis paper we sketch a possible mechanistic model for SMC motor proteins that make loops in DNA. This is a collaborative effort of @HaeringLab, JM-Peters, B-Rowland,. and us 1/

Lineage-specific 3D genome organization is assembled by IKAROS! A product of over 3yrs of truly joint work between our lab La Jolla Institute & Katia Georgopoulos' lab Harvard Medical School. Exceptional effort by the co-first authors Yeguang & Daniela. Out Cell authors.elsevier.com/c/1i821L7PXmeET

The EMBO workshop "Chromatin dynamics and nuclear organisation in genome maintenance" will take place from June 17-20, 2024, in Leiden, the Netherlands. Check our fantastic list of speakers and register before April 1, 2024 at meetings.embo.org/event/24-chrom…. Speaker slots available!

This was a much needed answer to an important question emerging from Hi-C-type studies, seeing promoters coming together in 3D space. Well done, Eileen Furlong team!

It is official, just over 1(!) year after the preprint, our work characterising GBM patient-derived lines and relapse via Hi-C led by Ting Xie is now out in Nature Communications. You can find the full PDF here: rdcu.be/dHrrD ...and a tutorial in my earlier thread below ->

Extensive folding variability between homologous chromosomes in mammalian cells biorxiv.org/cgi/content/sh… #bioRxiv

🧠Reminder: #register now to #JoinUs virtually for the MD Anderson Cancer Center Inaugural #BrainTumorCenter Trainee #Symposium: bit.ly/3yN15FO🧠 Agenda features renowned speakers and impactful presentations⬇️ 🗓️Friday, Sept. 13 🕗8 a.m.-3 p.m. 🖥️Virtual conference #EndCancer

I’m excited to be invited to speak at the UT MD #BrainTumorCenter Trainee Symposium on Sept 13 at MD Anderson Cancer Center. I will present my work on the 3D genome in glioblastoma😊😊😊. Register here: mdanderson.cloud-cme.com/course/courseo…

The Vassilis Roukos lab led a new and detailed study of Topoisomerase II contribution to #3Dgenome folding in human cells and in different cell cycle phases -- my group and the MundlosLab contributed analyses/data. The paper is now published in Molecular Cell ...1/n