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T1D and other autoimmune diseases (AIDs) co-occur in families. How parental AIDs impact T1D risk in offspring and how much of the familial risk is explained by HLA and non-HLA variants? 👩🏻‍🦱🧔🏻‍♂️👶🏻 Find out more from this thread 🧵 and our new preprint ⬇️!medrxiv.org/content/10.110…

📢 New pre-print! We tried to understand why autoimmune disease and type 1 diabetes co-occur in families using nationwide registries and genetic data. FIMM HelsinkiUni FinnGen #FinRegistry HiLIFE_Helsinki 👇👇👇👇

Exploratory physiological experiments are not clinical trials. Letter to the Editor at Cell Metabolism authors.elsevier.com/a/1i%7EWj5WXUl…

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency, say Matthew Johnson (@mbjohnson_), Masato Ogishi (Masato OGISHI), Clara Domingo-Vila (Clara Domingo Vila), Casanova Lab, TImothy Tree, Richard Oram and colleagues: hubs.la/Q02tkwK00

New! Online now: TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis dlvr.it/T61Rf0

Burden of reanalysis? A new study showed efficient reanalysis strategies by tracking updates in reputable clinical databases bit.ly/44fXXNU #GIMO #reanalysis #ClinVar #ACMGGuideline #screening #efficiency

More heterogeneity of gestational #diabetes Diabetologia link.springer.com/article/10.100…

A splice site variant in MADD (a T2D gene) results in reduced beta cell number and increased proinsulin-to-insulin ratio in stem cell derived islets. Beautiful work by Taneli Raivio and colleagues Timo Otonkoski Jonna Saarimäki-Vire , congratulations!

⁦Anna Gloyn⁩ gave a superb talk at ⁦FIMM HelsinkiUni⁩ ⁦Centre of Excellence in Complex Disease Genetics⁩ combining high-level genetics with deep in-vitro phenotyping

Kesäkuuntelemista 🎧🔅🌳 Tieto geeneistämme karttuu vauhdilla. Miten geenitietoa voidaan hyödyntää terveydenhoidossa? Tehdäänkö tulevaisuuden lääkärin tai ravitsemusterapeutin vastaanotolla geenitesti? Tiedekulma ➡️ open.spotify.com/episode/5218dx…

The remarkable mechanisms of SGLT2 inhibitors #heartdisease A robust specific off-target activation of PANK1 by SGLT2i promoting CoA synthesis and efficient fuel use in human hearts, a likely explanation for the clinical benefits of SGLT2i. biorxiv.org/content/10.110… The Arany lab

As partners in the #HorizonEU WISDOM project, FIMM and VEIL.AI will collaborate to design data framework & data protection and analysis solutions, enabling development of better treatment and diagnosis of patients with chronic immune-mediated diseases. helsinki.fi/en/hilife-hels…

Our sequencing of >1000 FinnDiane Study participants with #T1D reveals novel variants, genes (LTA/TNF-b), and regulatory regions (METTL4) associated with diabetic kidney disease @folkhalsanRC rdcu.be/dQts7

Do you have a promising biomarker that you're eager to validate in a clinical trial? Join us as we explore the journey from biomarker discovery to clinical trial execution, providing valuable insights and practical guidance for researchers and clinicians: helsinki.fi/en/hilife-hels…

#HiringNow: #Postdoc positions open for enthusiasts of pancreas development, #stem cell-derived islets and #diabetes at our new lab University of Helsinki Medicine and Health, University of Helsinki STEMM Research Program . Join our team in Finland 🇫🇮, happiest country in the world! Apply by 15.10.24: jobs.helsinki.fi/job-invite/348…

Next MetaStem PhD to be 🎩 Enjoy your day Hazem

Our News & Views in Nature Metabolism about Prof T Hansen s paper on the genetics of glycemic control post glucose load. New progress in insulin secreting cell’s function indeed ! Juleen R. Zierath

Huge thanks to the fantastic team of collaborators:Niels Grarup, Sevda Gheibi, LUIS RODRIGO CATALDO, @hinmul, R. Prasad, Tiinamaija Tuomi, M. Lakkso, Marta Guindo, R. Loos, Tune H. Pers, Daniel Witte, A. Linneberg, A. Astrup Tarunveer Singh Ahluwalia, P. Damm and many others. Looking forward to future collaborations!

Why do children with Type 1 Diabetes (T1D) often have parents with autoimmune diseases? Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants. 🔗 cell.com/cell-genomics/…