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Variants in TBC1D8B cause isolated nephrotic syndrome. This study found variants in TBC1D8B are not infrequent among patients with FSGS. TBC1D8B, functioning in endosomal maturation and degradation, is essential for nephrin trafficking bit.ly/j2022030275 @MartinHelmstdt1

Still think it's fun to watch slit diaphragms of #nephrocyte disintegrate after acute Rab5 silencing

The registration for our International SFB1453 Symposium is now open! Join us for 4 days of exciting kidney science, brilliant speakers and a fun social program here in the Black Forest! sfb1453.uni-freiburg.de/symposium #NephGenSymposium #NephGenSymposium2023 #NephTwitter

Had a great time at #pod23 🐙. Thank you so much to the organizers, especially the hosts Katalin Susztak and Larry Holzman. Looking forward to Hamburg! Tobias B. Huber

#Nephpearls #Nephrology thelancet.com/journals/lance…

Using the glomerular basement membrane model in Drosophila nephrocytes, this study reveals that matrix receptor-mediated cues ensure correct positioning of the slit diaphragm and the overall filtration barrier architecture bit.ly/JASN0400 @MartinHelmstdt1

Now open access in NDT Extrarenal manifestations in inherited kidney diseases 🧐The interplay between genetic variants and molecular pathways underscores the importance of exploring the extrarenal aspects of inherited kidney diseases. ▶️academic.oup.com/ndt/article/do…

The Drosophila slit diaphragm looks like a fishnet. It appears that the molecular architecture of the kidney slit diaphragm is evolutionarily conserved from Drosophila to mice! biorxiv.org/content/10.110…