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Two papers in two days for the #KarikariLab. Paper 1 gives guidelines for blood biobanking to support biomarker studies. Paper 2 reports association of plasma biomarkers with baseline cognition & longitudinal change in the population-based MYHAT study. Pitt Psychiatry Pitt's Alzheimer's Disease Research Center

- #Alzheimer blood biomarkers are great. - But many centers lack resources for cold storage of blood. - We examined if blood tubes with protease inhibitors can stabilize plasma biomarkers at room temp. onlinelibrary.wiley.com/doi/10.1111/jn…

Really excited to introduce everyone working in the #KarikariLab. I am fortunate to have an amazing group of scientists in the group dedicated to #ENDALZ. Pitt Psychiatry Pitt's Alzheimer's Disease Research Center Thread 👇🏾

Delighted to share the latest manuscript from the #KarikariLab Karikari Lab, presenting a first independent evaluation of the new NULISA proteomic platform from AlamarBio. Access the paper here - …arneurodegeneration.biomedcentral.com/articles/10.11…

Latest publication from the #KarikariLab Karikari Lab. We evalauted plasma p-tau217 and p-tau181 in a mild cogntively impaired (MCI) cohort recruited for a therapeutic trial. Where do plasma biomarkers fit in with current Alzheimer's disease detection? ajgponline.org/article/S1064-…

Neuronal plasma biomarkers in acute ischemic stroke. A masterpiece led by Fernando Gonzalez and our Norwegian collaborators. journals.sagepub.com/doi/10.1177/02…

Delighted to have been recognized as a "Highly Cited Researcher" in the list released by Clarivate today. Thank you to everyone who has contributed to my career thus far.

Longtime #Alzheimers physician and expert Oscar Lopez has joined the Alzheimer's Association board of directors. The news marks the first time a Pittsburgh-based scientist and researcher will be on the board. Full story via Hanna Webster @hannamwebster.bsky.social & Pittsburgh Post-Gazette 👇 post-gazette.com/news/health/20…

Department of Psychiatry Faculty Rank Among the Top 1% of Cited Works in 2024 psychiatry.pitt.edu/publications-d…

Check out the latest preprint from the Karikari Lab. We evaluated blood 🩸 assays on the NULISA proteomic platform from AlamarBio to detect brain amyloid pathology and neurodegeneration in the ethnically diverse HCP cohort led by @AnnCohenWilson2. Coming soon in Alzheimer's & Dementia Journals.

From the MYHAT-Neuroimaging study comes this masterpeice led by Andrea Weinstein, published in the Journal of Alzheimer's Disease. Multimodal neuroimaging biomarkers and subtle cognitive decline in a population-based cohort without dementia journals.sagepub.com/doi/10.1177/13…

Best of luck in your industrial internship, Yijun. Yijun

Pleased to share the last publication from the Karikari Lab in 2025. Thank you to all our friends, collaborators, allies, and colleagues who continue to make our stay in Pittsburgh delightful and our work impactful. medrxiv.org/content/10.110…

Happy New Year, everyone! Looking forward to the best in 2025.

The NIH funded Brain CHEC study aims to deepen relationships with the Black community in Pittsburgh, toward understanding root cause(s) of high dementia burden among Black individuals. With @AnnCohenWilson2, Jen Lingler, Dara Mendez & other amazing folks. health.pitt.edu/news/encouragi…

Glad to have you join us, Jim and You-Rim. Let’s go!

In Nature Medicine, we show: 1. P-tau262 & P-tau356 as markers of pre-tangle tau pathology; 2. Identify a core region that defines soluble tau assemblies (STA); and 3. Validate CSF STA assay in autopsy & tau PET cohorts. Congrats to all coauthors! nature.com/articles/s4159…

Thank you Jerome Staal and team for the fast and fair review process. We are confident that these findings will enable early and reliable detection of emerging tau aggregate pathology before mature tangles are formed. nature.com/articles/s4159…

nature.com/articles/s4159…

Congratulations to our lab members who presented their work at the Department of Psychiatry Research Day!