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In this joint collection Cell Stem Cell and StemCellReports (ISSCR) come together to share a collection on neuroscience models. Read now: hubs.li/Q02SV_kd0 Martin Pera

Here's an embryonic tortoise (~30 days old) developing within its egg 🐢🔬

Exciting science and amazing scenery at The Jackson Laboratory Diversity in a Dish meeting this week.

Really excited about this collaboration with Twist for extremely high-throughput genotyping via a library prep kit (and capture probes) plus analytics businesswire.com/news/home/2024…

How it started vs. how it's going, halloween edition

Looking forward to ASHG this week! I will be presenting work led by @aabiddanda and Sara Carioscia using data from >100,000 IVF embryos to discover genetic variants influencing meiotic recombination and aneuploidy at the opening session on Tuesday evening. #ASHG24 🧬🏔️

Excited to share our new preprint in which we address: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/15] medrxiv.org/content/10.110…

📢 New preprint alert: We’ve just published a deep dive into the role of tandem repeats (#TRs) in single-cell gene expression across the immune system, using #WGS and #scRNA-seq data from 1,790 individuals and over 5 million blood cells! 🧬 🧵👇 #repeats #SingleCell 1/9

Incredibly proud of PhD student Hope Tanudisastro from my team, who just gave a fantastic #ASHG24 talk on the impact of tandem repeat variation on cell type-specific expression. Check out her preprint: biorxiv.org/content/10.110…

Congratulations Laura to the award and your fantastic work!

Excited to share our latest preprint, as part of ENCODE4, on a consensus variant-to-function (cV2F) score for functionally prioritizing variants for complex disease - led by Tabassum Fabiha and co-mentored with Alkes Price. biorxiv.org/content/10.110…

Assistant, Associate or full Professor tenure-track faculty position job with Icahn School of Medicine at Mount Sinai - Institute for Regenerative Medicine | 666758 jobs.sciencecareers.org/job/666758/ass…

Beautiful work by the Stadtfeld and Thomas Vierbuchen labs on the role of genetic variation on imprinting and dna methylation stability in mouse pluripotent stem cells cell.com/stem-cell-repo…

New study shows genetic variation affects DNA #hypomethylation & imprint deregulation in naïve PSCs. Genetic variants may be potential biomarkers for epigenetically stable PSCs. ow.ly/aCVY50VilVY Weill Cornell Medicine Meyer Cancer Center Weill Cornell Medicine UMass Chan Medical School Memorial Sloan Kettering Cancer Center ISSCR

The latest work out of Weill Cornell Medicine proposes that genetic variants represent biomarkers to identify #pluripotent cell lines with desirable properties and may allow the targeted engineering of naive #PSCs with stable epigenomes. 🔗 StemCellReports | bit.ly/3DHaeSR

Modeling tissue-resident macrophage development from mouse pluripotent stem cells biorxiv.org/content/10.110… #biorxiv_devbio

Plasmid-based reporter assays are the bedrock of regulatory genomics. But a basic question has gone unanswered for decades: Do chromatin architectures form on plasmids transfected into mammalian cells—and does it matter? We finally have answers. biorxiv.org/content/10.110…

Using MRI images from 72 modern breed dogs & 13 premodern dogs: Modern breeds have expansions of neocortex & reductions in the amygdala & other subcortical regions. Cortical measures predicted individual variation in trainability & amygdala differences predicted fear scores. ...