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💔 Actinin mutations are linked to hypertrophic #cardiomyopathy, a heart wall defect. Using #CRISPR, #stemcells & #BioID, a new Cell Reports paper w JAX's Travis Hinson finds >300 interactions & a role w IGF2BP2 affecting metabolic adaptation to stressors: jax.org/news-and-insig…

brilliant work from now Gladstone Institutes investigator Catherine T, DVM, PhD | #BlackInCardio team from her postdoc in @JamesRPriestMD's lab. Genetics of aortic diameter and aneurysm risk, featuring our fave TFs HAND2 and TBX20! nature.com/articles/s4158…

Excited to report that our latest work using snRNAseq to dissect the molecular basis of end-stage DCM and HCM is now published nature. Large collaborative effort led by the incredibly talented Mark Chaffin Broad Institute. nature.com/articles/s4158…

Nature research paper: Integrated multiomic characterization of congenital heart disease go.nature.com/3OxLV9N

Thrilled to share our journey using single-cell multi-omics to do deep immunophenotyping in patients with ICI myocarditis Circulation #CardioOnc Sean M Wu, MD PhD Single Cell Media ahajournals.org/doi/10.1161/CI…

That winning feeling 😍 VAMOS CARLOS 🇪🇸 🌶 #essereFerrari 🔴 #BritishGP

Leclerc ⚔️ Perez ⚔️ Hamilton Incredible scenes at Silverstone 🍿 #BritishGP #F1

HFpEF-associated AF, a common clinical conundrum. Our recent Circulation study explored its molecular mechanisms. My first paper co-corresponding with amazing mentor Joseph hill! Many thanks to all coauthors! Gabriele G. Schiattarella Sergio Lavandero UTSW Heart ahajournals.org/doi/10.1161/CI…

Happy to share our paper on the role of CN in heart regeneration. Really proud of Nicholas Lam and Nguyen Ngoc Uyen Nhi for an outstanding job as they worked together to figure out why CN deletion induced heart regeneration but pharmacological inhibition did not.

We are thrilled to see our new paper out nature! (nature.com/articles/s4158…). We generated a spatially resolved single-cell multi-omics atlas of human myocardial infarction from 23 patients, spanning multiple tissue regions, including over 200k nuclei and 28 spatial samples. 1/n

Attempts to reinforce a leaky physician-scientist “pipeline" often turn to an institutional narrative. Here, we reflect on the application, interview, and match process as PSTP trainees. APSA Michael Rockman, MD, PhD Ben Reisman MD PhD Jamarius Waller, MD, PhD Yasmin Kamal, MD, PhD medrxiv.org/content/10.110…

#ResearchLetter: Chromatin accessibility signatures identify cardiomyopathy etiology, providing a molecular diagnosis that has potential to improve accuracy of cardiomyopathy classification Sam BhattacharyyaPhD #AHAJournals ahajrnls.org/3UbZaRf

With all eyes on Covid, it’s been easy to forget that HEART DISEASE is still the #1 killer worldwide. What do transcriptional enhancers have to do with it? Some insights from our latest work 🧵 cell.com/cell-reports/f…

Wow! Amazing way 2 start the week. Our recently accepted paper by William Goodyer, MD/PhD Francisco Galdos MD, PhD Lauren Duan Soah Lee w .@ChaitanKholsa .Eben L Rosenthal, MD .Stephan Rogalla on In vivo visualization & molecular targeting of the cardiac conduct syst. made the cover jci.org/articles/view/…

ERLING HAALAND WON'T STOP SCORING 🤖

Welcome to our newest BIDMC IM Residency class! We are so excited for you to join us in Boston from medical schools all across the country and a big congratulations to all on #Match2023!

Join our growing team to find new treatments for genetic heart failure

Titin truncation (TTN) variants are a common genetic cause of DCM. #CRISPR technology may restore TTN protein levels and represents a potential therapeutic avenue for #DCM Anthony Pettinato, MD, PhD @greenberglab314 @justincotney Travis Hinson ahajournals.org/doi/10.1161/CI…