🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Congrats to @AnkeetBhattMD and the KP-VACCINATE team! ~4 million adults randomized in 4 weeks—the largest RCT ever fully embedded in a LHS. Testing CV-focused vs. usual care messaging to improve flu vaccination. Results soon. (sciencedirect.com/science/articl…). Tor Biering-Sørensen, MD, MSc, MPH, PhD Muthu Vaduganathan

CTCPR Trials & CIRL strongly represented at the annual Danish Cardiovascular Academy summer meeting: Flemming Javier Olsen on progeria and Julie Borchsenius on psoriasis!

Rationale, Design, and Baseline char. of KP-VACCINATE out in AmericanHeartJ. ~3.8 Million adults randomized in 2 integrated learning healthcare systems in ~4 weeks. To our knowledge, the 🌟largest RCT ever🌟 & fully embedded in routine case. Results soon sciencedirect.com/science/articl…

This trial builds on fundamental work from 3 Danish 🇩🇰 Nationwide RCTs (NUDGE-FLU, NUDGE-FLU2, NUDGE-FLU CHRONIC) which showed increase vaccination update with CV focused messaging, providing global evidence for this strategy. jamanetwork.com/journals/jama/… Tor Biering-Sørensen, MD, MSc, MPH, PhD Niklas Dyrby Johansen

🫀 Study by Camilla Ottosen from CTCPR Trials & CIRL : Diastolic dysfunction in hypertension is a key precursor to HFpEF — but remains hard to diagnose and treat. 🔍 Review covers pathophysiology, echo tools (strain, TDI) & clinical challenges. 🔗 doi.org/10.1093/ehjci/…

Please find the most recent publication from CTCPR Trials & CIRL in JAMA 👇 In this randomized experiment embedded within the recruitment of the world largest flu vaccine trial (DANFLU-2 trial), we testet which invitation letter would increase the likelihood of trial participation

Excellent infrastructure👏👏

Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL JAMA Brilliant design Tor Biering-Sørensen, MD, MSc, MPH, PhD. Another example of CTCPR Trials & CIRL leading rapid cycle randomized clinical trials at scale. Niklas Dyrby Johansen

Thanks Lars G. Hemkens for the positive feedback on our recently published ‘RCT within a large RCT’. We need to randomize to understand how we can improve processes in our society. The link to our ‘RCT within a RCT’ can be found 👇 jamanetwork.com/journals/jama/… CTCPR Trials & CIRL Niklas Dyrby Johansen

Such research has extraordinary return of investment. Funders need to know, consider and implement.

The very first paper from DANFLU-2 - the largest individually randomized influenza vaccine RCT ever conducted – is officially out in JAMA: An RCT embedded into the recruitment phase testing the impact of recruitment letter design and color scheme. ja.ma/3Gfixqa

Check out our webinar on various aspects of cardio-oncology recorded yesterday in Stockholm: dagensmedisin.no/dmarena/nordic… Dan Atar CTCPR Trials & CIRL RigsHeart 🫀🚨

A new Duke-led study of 570 patients with MALSD found a strikingly high incidence of heart failure. Read more about the study, which co-author Marat Fudim, MD MHS says show “a critical gap in the recognition and diagnosis of heart failure in this high-risk group.” dcri.org/news/study-rev…

💥 Can ischemic heart disease (IHD) sabotage AF ablation? ⚠️ Preexisting IHD: no effect on AF recurrence but new IHD AFTER ablation triples AF relapse risk! 🧪 Study by Caroline Espersen , Niklas Dyrby Johansen, Tor Biering-Sørensen, MD, MSc, MPH, PhD from CTCPR Trials & CIRL 🔗 doi.org/10.1016/j.hrth…

🫀 New findings from CTCPR Trials & CIRL long-term outcomes after infant coarctation repair. 🩺 17-year follow-up shows late hypertension isn’t tied to surgery type or early arch size. 📉 Points to growth dynamics as bigger factor. 🔗 doi.org/10.1016/j.jtcv…

We are hiring 👇 Come join our amazing team!

💉 Findings from DANFLU-1: High-dose flu vaccine (QIV-HD) may benefit CKD patients over standard dose 🔬 No effect modification by CKD status 📉 Fewer hospitalizations with QIV-HD 🧪Katja, Niklas Dyrby Johansen, Kira Janstrup & Tor Biering-Sørensen, MD, MSc, MPH, PhD from CTCPR Trials & CIRL 🔗 doi.org/10.1016/j.jacc…

💌 Can a letter save lives? NUDGE-FLU-2 randomized 880K+ older adults to digital nudges vs. usual care. Small but meaningful boost—especially in those unvaccinated last year. Effect sustained across seasons. By Niklas Dyrby Johansen, Kira Janstrup Tor Biering-Sørensen, MD, MSc, MPH, PhD 🔗 doi.org/10.1038/s41591…

In Denmark, I presented a special award – the “Future of Ukraine” distinction – to 11-year-old volunteer Jens Fogh Thomsen. Since last year, he has been handcrafting Easter decorations and, through their sale, has raised over 34,000 Danish kroner to purchase school backpacks and

💉High-dose flu vaccine cut deaths & pneumonia/influenza hospitalizations vs. standard dose—regardless of CVD in DANFLU-1. 📉 All-cause hospitalization effect varied by CVD status. 🧪 By, Niklas Dyrby Johansen, Kira Janstrup, Tor Biering-Sørensen, MD, MSc, MPH, PhD CTCPR Trials & CIRL 🔗 doi.org/10.1161/CIRCOU…