The intestine maintains a delicate balance in the body. This equilibrium is disrupted in parts of the organ in some diseases, but scientists don’t fully understand why. Now, researchers have created a blueprint of the gut that could address these questions broad.io/ImmuneSystem-I…

1/3 Thrilled to share exciting new work in nature by Toufic Mayassi, Chenhao Li, Åsa Segerstolpe, et al. Spatial profiling of mouse intestine reveals a landscape robust to perturbations in homeostatic drivers & adaptable in a spatially-restricted manner bit.ly/48ZzJKc

Chenhao Li Toufic Mayassi Chenhao Li Hi, please find the unroll here: threadreaderapp.com/thread/1859710… Talk to you soon. 🤖

It was such an experience working on this large-scale dataset and most importantly in the team with diverse backgrounds. I have learned so much from Toufic Mayassi and other members of Xavier Lab.

Huge congrats to Toufic and all! Been fortunate to witness this incredible piece of work come together over the years and all the hard work behind the scenes which led to so many surprising and interesting findings. Such as there is a very distinct middle colon region with

#WeekendRead! #LocationLocationLocation! Toufic Mayassi Xavier Lab &co show nature the regional specialization of the gut at the spatial (single cell) level: strong resilience after inflammation & ILC2 are key in middle colon to adapt to the microbiota nature.com/articles/s4158…

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. It’s available on Amazon: tinyurl.com/mx2hewen

Latest paper from lab, where Awad et al describe how cigarette smoke impacts that MAIT-MR1 axis and implications for lung diseases. In collaboration with Fairlie, Hansbro and Corbett labs doi.org/10.1084/jem.20… Monash Biomedicine Discovery Institute NHMRC Wael Awad Monash University Prof. Jamie Rossjohn Journal of Experimental Medicine

Mouse gut blueprint: regionality and resilience dlvr.it/THdlNS #immunology

Our most recent work on sphingolipids is now published in Cell Host & Microbe! cell.com/cell-host-micr… Here we discovered a mechanism by which bacterial sphingolipids in outer membrane vesicles promote anti-inflammatory responses in immune cells, through activation of the mevalonate