How does tumor heterogeneity impact #metastasis? I am excited to share our latest pre-print: We used patient derived-xenograft models (PDX) of #breastcancer to examine the contributions of tumor heterogeneity on metastasis at single-cell resolution. doi.org/10.1101/2022.0… 1/n

Excited to share our lab's latest research, out today NatureStructMolBiol, which describes how 53BP1 controls DNA Repair in class-switching B cells & BRCA1 mutant cancers. Final article can be found here: nature.com/articles/s4159…; & the following thread walks you through the details

Thrilled to share my lab’s latest work, out recently in Mol Cell, on a role for HLTF in G4 resolution. Led by the amazing Gongshi Bai with essential contributions from @davidcortez, Brandt Eichman, Cejka Lab and The Boulton Lab. See: authors.elsevier.com/a/1jbBg3vVUPRm…

Congratulations to our #EMGS2024 EMGS Award winner: Dr. Andre Nussenzweig! This award is conferred in recognition of outstanding research contributions in the area of environmental mutagenesis. #EMGSAward

We are thrilled to present you our work on BRCA1-BARD1 nature showing that the complex has a direct role in long-range DNA end resection. With Ilaria_Ceppi Maria Rosaria Dello Stritto and our collaborators Pablo Huertas' Lab Sylvie Noordermeer and Seidel labs. nature.com/articles/s4158…

Cool role for replication timing and ATR in aging: "IF aging is due to replication stress induced by cryptic DNA damage, it may explain the conundrum why slowly proliferating tissues, eg liver, age faster than highly proliferating tissues eg intestine." cell.com/cell/fulltext/…

Our Review on “Aneuploidy as a driver of human cancer” is out in Nature Genetics. Check it out! 🎉 The Ben-David lab wishes everyone Shana Tova — may the new year be much better than the ending one, bringing peace and stability to all! 🙏 nature.com/articles/s4158…

Molecular mechanism of parental H3/H4 recycling at a replication fork nature.com/articles/s4146…

Very excited to present the latest preprint from our lab! "FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments" biorxiv.org/content/10.110… .

News: Researchers uncover new role of mutant proteins in some of the deadliest cancers nih.gov/news-events/ne…

PRESS RELEASE: NCI scientists and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface. go.nih.gov/xO7xUBL

#Chromothripsis leads to the acquisition of multiple genomic aberrations. Simovic-Lorenz & Ernst (DKFZ) discuss mechanistic models of chromothripsis, outline its role in cancer development + tumour evolution & suggest therapeutic vulnerabilities. 📖👇 bit.ly/4fy8pFo

Very excited to be involved in this study: HDAC6 sensors valine deprivation and moves to nucleus->actives TET2->TDG dependent DNA damage. Huge congrats to Dr. Ping Wang and the team, also to my talent postdoc Shuheng Wu who joined as a co-first author. nature.com/articles/s4158…

Exciting new discovery led by National Cancer Institute uncovers a new role of mutant RAS in driving cancer growth – by helping release a nuclear protein (EZH2) into the cytoplasm, which then facilitates the breakdown of a tumor suppressor protein and tumor growth. cancer.gov/news-events/pr…

"Genome editing with the HDR-enhancing DNA-PKcs inhibitor AZD7648 causes large-scale genomic alterations" Cullot G [..] Corn JE. Nat Biotechnol. 2024-11-27. doi.org/10.1038/s41587… #CRISPR-Cas9 … kilobase- & megabse- scale deletions, chromosome arm loss and translocations.

Check out latest from the Walter-Pellman collaboration, revealing how the replisome is remodeled in mitosis to allow CMG eviction, which we propose minimizes fallout from under-replication. biorxiv.org/content/10.110…

In the latest issue! How to build the virtual cell with artificial intelligence: Priorities and opportunities dlvr.it/TGlk0n

Congratulations Sounak Sahu, Mélissa Galloux, members of our BRCA Variant Analysis Unit National Cancer Institute for this outstanding work. Sincere thanks to our collaborators Drs. Chari, Papaleo, Michailidou and their team members.

Cancer cells leverage epithelial-to-mesenchymal transition (EMT) to promote treatment resistance and metastasis. Results from a recent MD Anderson study found that EMT is a necessary step for pancreatic tumors to become malignant. Learn more: brnw.ch/21wR9Zv #EndCancer

PAPER OUT!! 🥳🎉💃🏻🕺🏻💃🏻🕺🏻 A redefined InDel taxonomy provides insights into mutational signatures ⁦Nature Genetics⁩ Brainchild of the amazing ⁦Gene C. Koh⁩ Tweetorial below!! 👇 1/n nature.com/articles/s4158…