🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Congrats to David Gate Naresha Saligrama and Tony Wyss-Coray team on this game changing story about CD8 T cells in Alzheimer’s disease!

Lipid-droplets in microglia underlying aging and AD! The Tony Wyss-Coray lab is on fire! So proud of my former labmates!!

Incredible story and amazing work by Gunsagar Gulati Stanford Medicine Will be a great resource for any one interested in scRNA-seq analysis!

COVID19 shutdown science and magnified the systemic issues plaguing academic science, including the lack of diversity. This, in combination with the current environment of racial injustice, highlights the need for a better 1/n cell.com/cell/fulltext/…

An excellent paper Neuron by Huang, Woo et al from the Deneen lab BCMHouston Proud to write a Preview for this piece: authors.elsevier.com/a/1bFWj3BtfGx3… Region-Specific Transcriptional Control of Astrocyte Function Oversees Local Circuit Activities cell.com/neuron/fulltex…

Congrats to graduate students Nora Abduljawad Nicole Hamagami! Many thanks to BIG Center @WashU @WUADRC for supporting our research! Looking forward to the collaboration with Gabel Lab !

Very excited to share our new story on the "missing link" for brain's immunity || Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma science.sciencemag.org/content/early/…

Do you know a senior PhD student that is excited to share their research? Apply to Wash U INSPIRE. One week left before the application deadline.

Faculty JOB ALERT! @WUSTLneurosci is hiring at all levels in the broad neuroscience field! Glia enthusiasts are encouraged to apply and join our vibrant community! Announcements are here: neuroscience.wustl.edu/opportunities/… and here: neuroscience.wustl.edu/opportunities/… Feel free to DM!

Imagine we developed a drug to repair synapses and neurons and learned that the supply routes keeping neurons alive are broken in AD brains - it’s a possibility. Check out Andrew C. Yang ’s human brain vascular atlas rdcu.be/cGZ2D and the related study from Heiman/Kellis

Online now: An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination dlvr.it/T7chfB

Walking into my office with this pleasant surprise!! This reminds me how lucky I am to have the privilege to work with these extremely talented scientists and kind human beings! Thank you all for this!

Finally out! Check out our new paper in Nature Communication 10.1038/s41467-024-49596-0. In this new study, we established that microglia make their own TGF-β1 ligand to maintain brain homeostasis and cognitive function via autocrine signaling mechanism at a single-cell level!

We are  excited   to share new paper led by the talented Nicole Scott-Hewitt that a microglial C1q, can be  internalized by neurons in the healthy aging brain, undergoes liquid-liquid phase separation (LLPS), integrates into neuronal RNPs and impacts neuronal proteostasis 1/3

The WashU Medicine Genetics 2024-2025 Seminar Series schedule is here! 👇Visit our website for the full seminar schedule: genetics.wustl.edu/events/ Here's to another year of successful presentations! Many thanks to our organizers Tychele Turner, Tristan Qingyun Li and administrative staff!

Some cool new microglia replacement systems in which we show brain macrophages are sufficient to drive interferonopathy in a model of Aicardi Goutieres syndrome. Work by @Kel_Nem with Chris Bennett ... and our lab's (MBL) first paper!

Circulatory proteins shape microglia state and boost phagocytosis biorxiv.org/content/10.110…

Thrilled to share new work from our lab led by ⁦Mitchell (Min Woo) Kim⁩! The results provide new insight to immune privilege and hopefully diagnostic/therapeutic tools || Endogenous self-peptides guard immune privilege of the central nervous system | Nature nature.com/articles/s4158…

Microglia cannibalism!!!!

It was a honor to highlight these two important papers on microglia replacement with Jingyi Yang in the lab! Congrats again to Chris Bennett Mariko Bennett MD PhD (she/her) Movahedi Lab !