How do cells clean up misfolded proteins when they divide? This study finds that the cleanup crew includes the ER chaperone BiP and the proteasome, and kicks in right as cells finish dividing. Surprisingly, one major cell cycle regulator isn’t involved. elifesciences.org/articles/96675…

New research in Science greatly expands the potential target scope of molecular glues and should stimulate the development of new small molecules that can selectively target therapeutically relevant proteins for degradation. Learn more in this week's issue:

Happy to share our latest work on the specific role of phosphatase PLL2 in phytocytokine as opposed to MAMP signaling nature.com/articles/s4147… Big congrats to 1st author Rong Li !

Chocolate consumption enhances cognitive function. There is powerful correlation between chocolate intake & the number of Nobel Prize recipients.

SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress (Ruihua Huang , Mengrui Wen , Bojin Feng , et al) doi.org/10.1093/plcell… ASPB #PlantSci

Online now! Site-resolved assessment of targeted protein degradation dlvr.it/TLn8Bk #chembiol

Are mini proteins the new antibodies? Mini proteins are highly stable, easy to manufacture, and very quick to design thanks to recent AI methods. Unlike mAbs, there is a large body of structural data to train machine learning models on to generate de novo mini protein binders.

RNF114 is an E3 ligase that can recognize ADP-ribose and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites nature.com/articles/s4158…

🆕 JUST OUT: #Extracellularvesicles: cargo loading, degradation and secretory pathways, and their intersection with #autophagy Prof. Kasper M.A. Rouschop（Maastricht University Medical Center+） 💥 Read now: oaepublish.com/articles/evcna… #EVs #Exosomes Takahide Matsui/松井貴英,Sanjeev Shukla

Undruggable ‘disordered’ proteins become druggable with new AI techniques from David Baker. Science Magazine science.org/doi/10.1126/sc…

💚My New Cover for Woo Lab Harvard University 💙 This art illustrates the discovery that #cereblon, a key protein in the cell’s waste disposal system, recognizes small chemical tags called #cyclic_imides (shown here in green at the tips of proteins). These naturally form at the end of

Finally published. A big thank you to all contributors: Barley resistance and susceptibility to fungal cell entry involve the interplay of ROP signaling with phosphatidylinositol‐monophosphates - Weiß - 2025 - The Plant Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/tp…

PepMLM is out in Nature Biotechnology! 🎭Want a short binder for any target? Just input its sequence + desired binder length → PepMLM unmasks it. Simple? No way? The results speak for themselves. 👇 📜: nature.com/articles/s4158… 💻: github.com/programmablebi… 🤗: huggingface.co/ChatterjeeLab/…

A review coauthored with Dr. Shuai Huang of Ohio State University on the role biomolecular condensates in plant immune regulation. This emerging field is fascinating, yet still awaits major technological advances to move beyond current limitations. authors.elsevier.com/sd/article/S19…

Natural plant populations maintain diverse resistance genes, but crops often lack this diversity, making them vulnerable to rapidly evolving pathogens. Xiaoxiao Zhang et al. used DNA shuffling on barley Mla7 and Mla13 genes to create MLA variants, some gaining the ability to

Back from holidays. During this time, we published two papers about engineering FLS2-flg22 perception, to expand the recognition spectrum, and one News & Views highlighting them: rdcu.be/eBbgd rdcu.be/eBbgk rdcu.be/eBbgm

A new #ScienceReview looks at a different approach to drug discovery that may enable drugging of unconventional targets through stabilization of macromolecular complexes with molecules known as “LOCKTACs.” Learn more: scim.ag/4lAiKmF

Insecticides made of RNA could offer a safer and more targeted weapon against crop pests. Learn more: scim.ag/41caemw #ScienceMagArchives

Photoexcited CRY1 physically interacts with ATG8 to regulate selective autophagy of HY5 and photomorphogenesis in Arabidopsis (Lu Jiang , Shilong Zhang , et al) doi.org/10.1093/plcell… ASPB #PlantSci

The Green Revolution saved 1-2 billion lives globally. Activists say it was a failure. They’re lying! ⁦Stuart Smyth⁩ geneticliteracyproject.org/2025/08/25/vie…