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Our latest preprint is online. Thanks to many in the lab for contributing to building these cell lines over the years including James’ and Alberto’s key contributions. biorxiv.org/content/10.110…

A nice piece by Michelangelo Marasco and Sandra Misale on recent findings on genetic and non-genetic mechanisms of resistance to KRAS inhibition, including work by our own Anupriya Singhal.

Amazing technology and findings that may enable a cure for pre-eclampsia! Congrats Mike Mitchell and team!

Awesome work by Thomas Norman enabling RNA and chromatin accessibility readouts in Perturb-Seq experiments. Congrats to all involved!

Excited for this meeting with the AACR and our Japanese colleagues!

Very cool new approach by the Andrea Ventura lab to engineer ecDNAs in mice that immediately reveals cool new biology! Lots of new questions to address.... Congrats to the team!!

In case you missed it, we’re hiring a lead position for the RNA Therapeutics Lab in the Olayan Center for Cancer Vaccines Memorial Sloan Kettering Cancer Center. If you're a visionary leader with expertise in RNA-based therapies, please consider applying! externaltalent-mskcc.icims.com/jobs/80006/sci…

Very excited to share our new paper out in nature today, led by my amazing postdoc, Qingfei Zheng (now at Purdue University) in collab w/ The Maze Lab (with Li & The Muir Lab) showing a beautiful mechanism of monoamine modification swapping in neurons 🤩 rdcu.be/d5CNc

Stem cell fitness ⬇️with age, possibly suppressing tumorigenesis, but the risk of cancer⬆️with age, showing the complexity of this. Xueqian Zhuang, Tuomas Tammela et al. explore this relationship in tumour-initiating alveolar stem cells in the lung. 📖👉 bit.ly/4agBwew

💡Online now! RESEARCH HIGHLIGHT: We speak with Tuomas Tammela about their new work demonstrating age-related decline in the stemness of epithelial stem cells limits tumorigenesis. doi.org/10.1038/s43587…

Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏾💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Cancer Discovery aacrjournals.org/cancerdiscover…

A great opportunity to train with an inspiring and talented chemical biologist, who also happens to be an awesome human being. Excited to see what the JuanmaPovedano lab gets up to!

Exciting new work from Yael David in collaboration with Robert Schwartz and #VivianaRisca on how hepatitis B hijacks the host cell's chromatin remodeling machinery to drive infection, revealing a new therapeutic entry point. Congratulations!

Congrats Carmofon Lab for a beautiful study revealing cooperation of cancer cells in nutrient scavenging through aminopeptidases. A super cool take on evolutionary biology and a new example of how cancers benefit from intra-tumoral heterogeneity.