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👩‍🍳🔪New cover from the studio🔬! Molecular Cell In the paper, Kwamina Nyame Monther Abu-Remaileh et al. characterize lysosomal phospholipid catabolism, a pathway crucial in several biological processes, and reveal a pathological role for the Batten disease storage metabolites

Glycerophosphodiesters inhibit lysosomal phospholipid catabolism in Batten disease dlvr.it/T56sQT

Our studio has produced the cover illustrations on the last two issues of Molecular Cell ! Can we make it three in a row? Putting it out into the universe! 🌟 Fingers crossed! Take a moment to revisit the papers behind these two cover designs! 📖🔍 - "Glycerophosphodiesters

Excited and grateful for the opportunity to present at Bay Area Aging Meeting yesterday

Super excited and out today: Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples biorxiv.org/content/10.110…

Very excited to share our recent discovery of PLA2G15 as a lysosomal BMP hydrolase whose targeting ameliorates lysosomal disease. We establish the rules that govern BMP catabolism, a key lipid implicated in multiple neurodegenerative diseases and lysosomal disorders @abu_remaileh

Excited to share our comprehensive work on BMP catabolism and truly grateful of the enjoyable journey of this discovery with my great science buddy Kwamina Nyame Kwamina Nyame and my wonderful mentor Monther Abu-Remaileh Monther Abu-Remaileh

Absolutely beautiful work Monther Abu-Remaileh and Kwamina Nyame that will be important for #lysosomal storage disorders and in understanding the regulation of BMP lipids. Definitely a tour de force to probe lysosomal biology!

Another bombshell discovery by @abu_remaileh’s lab Sarafan ChEM-H, congratulations first author Kwamina Nyame and coworkers!

Congrats Jian Xiong (熊剑)

Work led by Kwamina Nyame & Jian Xiong in the lab of Institute Scholar Monther Abu-Remaileh identified the enzyme PLA2G15 as a lysosomal degrader of BMP, a lipid that is misregulated in neurogenerative disease, providing a potential new access point for treatment: news.stanford.edu/stories/2025/0…

One of my favorite parts of this story is the behind the scenes where we were able to work with Monther Abu-Remaileh and Kwamina Nyame on a second Pla2g15 paper. Science is great because it’s not isolated discoveries but validation by multiple groups. nature.com/articles/s4158…

For neurodegenerative diseases like Alzheimer’s and Parkinson’s, treatment options are scant. New research identifies a promising access point to therapeutics. news.stanford.edu/stories/2025/0…