We have recently published an exciting new study in collaboration with the Hatter Cardiovascular Institute, UCL on the effect of SGLT1 on glucose-mediated exacerbation of the ischaemia reperfusion injury model in the heart! Check out the publication here 🫀 - pubmed.ncbi.nlm.nih.gov/39088085/#full…

New preprint w. Eva Maria Funk & René Hägerling + lab Charité - Universitätsmedizin Berlin: we made a new tool to label lymphatics: anti-LYVE1 single-domain antibodies, AKA nanobodies (👇 video of kidney lymphatics, nanobody in white) Many other potential uses! biorxiv.org/content/10.110… UCL Child Health Kidney Lab

Several years ago, Jennifer Chandler from UCL Child Health Kidney Lab aimed to study glomerular cell crosstalk in a model of childhood kidney failure The result: our first single-cell study, in Journal Of Pathology. Impaired angiogenic signalling is an early driver of disease …thsocjournals.onlinelibrary.wiley.com/doi/10.1002/pa…

In my Kidney Research UK Fellowship, I want to improve understanding of #childhood #kidneyfailure and how we treat it. So we used #singlecell #RNAseq to deep dive into #glomerularcell #communication in disease to find out! Published in Journal Of Pathology ⬇️ (1/9) shorturl.at/8QC1Q

Congratulations to Jennifer Chandler and the rest of the team on this exciting new work! If you want to learn more about the #scRNAseq analysis of glomerular communication in childhood kidney failure Jennie has done, check out the tweetorial below 👇

Check out this RED-iculously fascinating image on #Red4Research day 🔬 Teams at GOSH, @UCLChildHealth and Hôpital Necker AP-HP have identified a feature of a rare kidney disease in children that could help develop better treatments. Find out more: gosh.nhs.uk/news/potential…

New paper in ASN Kidney360 with Encelo describes new method to obtain cells from urine of children and adults with kidney and bladder conditions. Funded by Kidney Research UK and Great Ormond Street Hospital for Children the cells can improve diagnosis and test new treatments. journals.lww.com/kidney360/full…

Vangl2, #PlanarCellPolarity protein, in Kidney Morphogenesis Vangl2 lp/lp🐭 👉Kidney Hypoplasia e13.5~18.5 👉⏬Ureteric Budding/#BranchingMorphogenesis e13.5 👉Absent renal pelvis e18.5 👉Lack bush border/epithelial microvilli in proximal tubule e18.5 👉Smaller Glomerular tufts;

Read about Dr Jennifer Chandler and the team's latest research finding! They have seen that disrupted messaging between kidney filter cells could be an early feature of a childhood kidney disease and offer a potential treatment target. “This research takes us one step closer to

We are hiring! Looking for a pre-doc / post-doc scientist (or clinician!) to join us UCL Child Health Kidney Lab You’ll work between UCL Great Ormond Street Institute of Child Health & Great Ormond Street Hospital for Children investigating what lymphatic invasion does to childhood kidney cancers. Please apply before 23/10 tinyurl.com/4d427uep

Happy to share our latest manuscript now out in Cell Reports! In lieu of a Tweetorial, I'll post amazing images from the manuscript and please check out the article for our spatiotemporal mapping of kidney innervation and new findings! cell.com/cell-reports/f…

We have a new pre-print out! Working with Ruth Pepper we describe an adult patient with FSGS treated with Vincristine, and studied how serum from this patient affects human podocytes in vitro. Check out our work below ⬇️ UCL Child Health Kidney Lab UCL Renal biorxiv.org/content/10.110…

📢CALL FOR ABSTRACTS 🚨2nd REOLUT Conference 📅26 March 2025 🏢Hyatt Regency Manchester Spaces are filling up to present your work! Don't forget to.. ✨Register: buytickets.at/rdrukepigenrar… ✨Submit your abstract: forms.office.com/e/Y6SiDDBZmj Bill Newman Melanie Chan Rare Disease Research UK

gosh.nhs.uk/working-here/w… Here is an excellent opportunity to join our wonderful GOSH team with two locum consultant paediatric nephrologist posts from September 2025 GoshRenal UCL Child Health Kidney Lab

We are shining a spotlight on Dr Jennie Chandler for #InternationalWomensDay! As a recipient of a Kidney Research UK intermediate fellowship grant, Jennie is leading ground-breaking research within the kidney development and disease group at UCL Great Ormond Street Institute of

As part of #BritishScienceWeek, we’re shining a spotlight on Emily Moore, a dedicated PhD student at UCL Great Ormond Street Institute of Child Health. Emily’s research is investigating new treatments for children with kidney disease by studying glomerulosclerosis, which

Thrilled to share a new output from my PhD in David Long’s UCL Child Health Kidney Lab lab UCL Great Ormond Street Institute of Child Health, published in DMM Journal doi.org/10.1242/dmm.05… We studied kidney microvascular changes in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)

Thanks Biomedical Picture of the Day BPoD for highlighting our recent work published in DMM Journal The Company of Biologists.

Congratulations to Daniyal Jafree from Developmental Biology & Cancer, GoshRenal and UCL Renal for excellent basic science oral abstract presentation covering the role of lymphatics in allograft inflammation and rejection noting the tolerogenic immune profile of lymphatics ESOTtransplant #ESOT2025

🔔 New publication 🔔 📑 Our new collaborative publication with the Royal Free Hospital and Children’s Hospital Los Angeles is now online in Kidney International Reports: kireports.org/article/S2468-… 🤩 A special one for me, as it is my third first-author publication