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Therapeutic drug monitoring‑guided pip/tazo infusion vs fixed dose (13.5 g/24 h if eGFR ≥20 mL/min) in #sepsis, TARGET RCT: 🧪no significant difference in mean SOFA ⬇️28-day mortality + ⬆️ clinical/microbiological cure if TDM (no statistical significance) rdcu.be/cGcvT

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1/9 #RRAM Heparin vs Citrate anticoagulation for CRRT in intensive care: the RRAM observational study journalslibrary.nihr.ac.uk/hta/zxhi9396/#… 182 ICNARC Critical Care units (2009-2017 = pre-pandemic) 60,416 RRT patients in heparin era 8,585 RRT patients in citrate era

Our thoughts and prayers are with you and yours 😥

So INCREDIBLY proud of Michael Griksaitis and the team of University Hospital Southampton 💙 and Southampton Children's Hospital staff who went on the mission, as well as all our other colleagues here and across NHS England who helped make it possible 💙 uhs.nhs.uk/whats-new/news…

Are you an exceptional nurse leader? We University Hospitals Sussex are looking for three divisional directors of nursing to help lead our clinical divisions. As a senior member of the divisional and corporate nursing teams, you will make a difference to patients every day maggie davies 💙 RN DCP (1/5)

One of our consultants mike margarson Is undertaking this challenge with the Intensive Care Society 💙 Please consider a donation to support Doctors In Distress Doctors In Distress Ztov2022.org. It’s turning into a proper challenge..

Today was brutal Intensive Care Society 💙 Doctors In Distress @ArdonaghCT But knowing the fabulous support at home certainly helped through the blood, sweat & a little tear!

Do you prescribe #NSAIDs after #colorectalsurgery? 💊💩 An updated centre-level analysis from the EuroSurg Students IMAGINE study has shown no difference in the risk-adjusted rates of anastomotic leak or AKI across data from 332 hospitals and 4590 patients! academic.oup.com/bjs/advance-ar…

Today we wish the happiest of retirements and fondest of farewells to our outstanding @UHSussex_CEO Dame Marianne Griffiths. After 43 yrs in the NHS and 13 leading #Sussex hospitals Marianne said she couldn’t be more proud of her #UHSussex colleagues #happyretirement Marianne

Daily dexamethasone 12 vs 6 mg for up to 10 days in #COVID19 pts with severe hypoxaemia, COVID STEROID 2 trial: NO significant improvements in mortality or HRQoL at 180 days but results most compatible with benefit from higher dose. #FOAMcc #COVIDFOAM 📎 rdcu.be/cKsnT

A widespread intervention in critical care over the past 20 years has been the use of induced hypothermia post cardiac arrest ➡️ A thread...... 1/24

Joint ICS, FICM & UKCCNA Position Statement on Critical Care Staffing Standards. 1/8 ics.ac.uk/Society/Policy…… Intensive Care Society 💙 FICMNews UK Critical Care Nursing Alliance

Congratulations to our Physiotherapist Louise who has just completed her #FUSIC Lung module. 🫁 🤜🎉

Our latest article published in Critical Care Our results suggest that (over)transfusion 🩸 in-ICU is associated with a higher 1-year mortality among in-ICU survivors with Alexandre Mebazaa #AntoineKimmoun and coworkers To learn more, read the article 👇 ➡️🔗tinyurl.com/ycu5mza5

Complications of regional citrate anticoagulation on #RRT Citrate accumulation/toxicity: 👉Metabolic acidosis 👉tCa/iCa >2.5 👉Potentially lethal (but rare) Citrate net overload: 👉Metabolic alkalosis 👉tCa/iCa <2.5 👉Benign (and easy to fix!) ESICM #LIVES2022 #AKI M Velia Antonini

hot take on the AID-ICU trial of haloperidol for management of delirium in ICU 🔥 this is the largest MC-RCT to date on haloperidol for treatment of delirium (in comparison, MINDS enrolled 192 patients in the haloperidol group). nejm.org/doi/full/10.10…

New subarachnoid haemorrhage NICE Guidance out. 3 key points. nice.org.uk/guidance/ng228… Royal College of Emergency Medicine Dan Horner @EddCarlton Matt Reed 1) If you aren't already, stop doing LPs if CT brain done within 6 hours of headache onset.

Peripheral noradrenaline vs metaraminol on ICU Metaraminol more $$$, no benefit Suspected noradrenaline extravasations required no additional management Small single centre study but in keeping with the body of literature on this topic journals.sagepub.com/doi/full/10.11… #Dogmalysis