🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Neutrophil prime unique transcriptional responses in journals.asm.org/doi/full/10.11… Mary O'Riordan Christiane Wobus Vincent Young Findings highlight importance of building more physiological infection models to replicate human infection conditions to study host responses specific to individual pathogens.

Effects of immunoproteasome inhibition on acute respiratory infection with murine hepatitis virus strain 1 J Virol journals.asm.org/doi/10.1128/jv… Jason B. Weinberg Findings indicate that the immunoproteasome is a critical protective host factor during coronavirus respiratory infection.

ID & characterization of the lipoprotein N-acyltransferase in Bacteroides pnas.org/doi/10.1073/pn… Nicole M Koropatkin @[email protected] Shows deletion of Lnb negatively affects cellular growth & ability to degrade polysaccharides, deepening understanding of Bacteroidota & lipoproteins.

Dev. of a suite of P. mirabilis-derived urea-inducible promoters journals.asm.org/doi/10.1128/ae… Harry Mobley Melanie Pearson Dev. of a urea-inducible system for selective gene expression is useful to the field of uropathogenesis as it enables selective gene induction during exp. UTI.

Development of a suite of Proteus mirabilis-derived urea-inducible promoters journals.asm.org/doi/10.1128/ae… PDK2468 Ffindings reveal the mechanism by which EPHB4 and RASA1 regulate the development of LV valves.

Apicomplexan Pore-Forming Toxins pubmed.ncbi.nlm.nih.gov/39088861/ @VernCarruthers Although exciting progress has been made in defining mechanisms of pore formation by PFTs, many questions remain to gain additional key insights into these remarkable determinants of parasitic infections.

TgATG9 required for autophagosome biogenesis/maint. of chronic infec in T. gondii pubmed.ncbi.nlm.nih.gov/39600488/ @VernCarruthers Molec. dynamics of autophagosome biogenesis w/in early-branching eukaryote/pinpoint indispensable role of autophagy in maintaining T. gondii chronic infec.

Variation in HIV-1 Tat activity is a key determinant in the establishment of latent infection pubmed.ncbi.nlm.nih.gov/39636695/ KLCollins Lab Results provide additional insight into the mechanisms of latency establishment and inform Tat-centered approaches to cure HIV.

Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases journals.asm.org/doi/full/10.11… Nicole M Koropatkin @ericcmartens1 Indicates gut microbiome may be a source of variable response to acarbose treatment for diabetes via complex mechanisms in common gut microbes.

The pneumococcal bacteriocin streptococcus B is produced as part of the early competence cascade and promotes intraspecies journals.asm.org/doi/10.1128/mb… @SuzyDawid Contributes to our understanding of the competitive interactions that precede the development of S. pneumoniae disease.

HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion biorxiv.org/content/10.110… Alice Telesnitsky When mutants that expressed only one RNA were forced to revert, they regained functions associated with the second RNA.

Neutrophil prime unique transcriptional responses in intestinal organoids during journals.asm.org/doi/full/10.11… Mary O'Riordan Vincent Young Christiane Wobus Findings highlight importance of building more inf. models to replicate human inf. conditions to study host responses specific to indiv. pathogens.

Effects of immunoproteasome inhibition on acute respiratory infection with murine hepatitis virus strain 1 journals.asm.org/doi/10.1128/jv… Jason B. Weinberg Findings indicate that the immunoproteasome is a critical protective host factor during coronavirus respiratory infection.

Adaptations & metabolic evolution of myzozoan protists across diverse lifestyles/environs journals.asm.org/doi/10.1128/mm… @VernCarruthers Understanding mechanisms of these traits has potential to spawn new interventions against medically/veterinary relevant parasites w/in the grouping.

Virus Evolution in Prolonged Infections of Immunocompromised academic.oup.com/clinchem/artic… @lauringlab Emerging methods incl. wastewater monitoring may provide a more sophisticated understanding of the impact of variants that evolve in immunocompromised hosts on the host population.

The mysterious case of missing lymphocytes: journals.physiology.org/doi/abs/10.115… Anukul Shenoy Cautionary tale against adopting lung dissociation protocols across institutions w/out reoptimization; careful inspection of cross-institutional reproducibility of previously described protocols.

Patterns of Klebsiella pneumoniae bacteremic dissemination from the lung pubmed.ncbi.nlm.nih.gov/39824859/ Michael Bachman Here, our data reveal unexpected heterogeneity in Klebsiella bacteremia dynamics and define a framework for understanding within-host bacterial dissemination.

mpactR: an R adaptation of the metabolomics peak analysis computational tool (MPACT) for use in reproducible data analysis pipelines | Microbiology Resource Announcements journals.asm.org/doi/full/10.11… @balunaslab The package is available through CRAN and GitHub.

Variation in HIV-1 Tat activity is a key determinant in the establishment of latent infection insight.jci.org/articles/view/… KLCollins Lab Results provide additional insight into the mechanisms of latency establishment and inform Tat-centered approaches to cure HIV.

Congratulations to Ande Garretto and her co-mentors Bob Woods and Suzie Dawid on her successful dissertation defense!