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Elucidating donor-specific #Thrombus growth through #Computational #3Dmodelling of #Platelet calcium mobilization, motion & bonding, agonist release & blood velocity field doi.org/10.1371/journa… #Atherosclerosis #TranslationalScience

World’s first: Gene editing clinically deployed for breakthrough treatment of rare genetic disease led by Kiran Musunuru & Rebecca Ahrens-Nicklas nejm.org/doi/full/10.10… #GeneEditing #CRIPR #OrphanDisease #CPS1deficiency #TranslationalScience

Discovering molecular lever that controls whether liver stores energy as fat or glycogen. Tuning this switch could open new paths to tackle #MetabolicDisorders. doi.org/10.1126/sciadv… #Ppp1r3b #HepaticMetabolism #TranslationalScience

Tissue-specific loss of #Tregs and rise of stem-like CD8+ T cells prior to the onset of #TypeIDiabetes may offer promising window for early intervention doi.org/10.1038/s41467… Betts Lab #Diabetes #T1D #ImmunePhenotype #Autoimmunity #TranslationalScience

Hope for children with #CLN2disease: #GeneTherapy enables steady-state protein delivery to the CSF in preclinical models doi.org/10.1126/scitra… #LysosomalStorageDisorders #RareDisease #OrphanDrugs #TranslationalScience

Cortical spreading depolarization (CSD) discovered as second brain event following controlled seizure induction during #ElectroconvulsiveTherapy (ECT) for #TreatmentResistantDepression doi.org/10.1038/s41467… #MentalHealth #TranslationalScience

Dissecting effects of #psychedelics at the cellular level to understand their therapeutic potential in #NneuropsychiatricDisorders nature.com/articles/s4159… #MentalHealth #PTSD #Depression #SubstanceUseDisorder #TranslationalScience

Dissecting effects of #psychedelics at the cellular level to understand their therapeutic potential in #NeuropsychiatricDisorders nature.com/articles/s4159… #MentalHealth #PTSD #Depression #SubstanceUseDisorder #TranslationalScience

Pairing high-resolution cryo–electron microscopy & tomography to design the next-generation broad-spectrum anti-influenza therapeutics science.org/doi/10.1126/sc… Yi-Wei Chang #Flu #FluVirus #CryoEM #CryoET #TranslationalScience

Engineering genetic approaches to develop a CAR-T cell therapy efficaciously targeting #SolidTumor doi.org/10.1016/j.ccel… Daniel Powell Lab @ UPENN #NeoCARs #CellTherapy #CARTCell #GeneTherapy #ImmunoTherapy #Oncology #TranslationalScience

Building the foundation to address the mechanistic gap between two hallmarks of #Neurodegeneration: excitotoxicity and RNA regulation by #RNA #BindingProteins (RBPs). doi.org/10.1016/j.isci… Kelly Jordan-Sciutto #NeuroSci #MolecularBiology #TranslationalScience

Unraveling the often undefined pathogenesis of #MyxomatousValveDisease (MVD) doi.org/10.1172/JCI186… #SignalingMechanism #ValveDisease #HeartValve #CardiacHealth #TranslationalScience

How do biological systems interact with foreign materials? How is decision-making reflected in biological signaling networks? Using complement activation as a model system doi.org/10.1016/j.cell… dives into these questions Jake Brenner #TranslationalScience

Exploring the potential to restore physiologic islet function through fully differ¬entiated, allogeneic pluripotent stem cell–derived islet-cell therapy for #Type1Diabetes nejm.org/doi/10.1056/NE… #StemCell #CellTherapy #TranslationalScience

Broadening clinical utility of #CARTcelltherapy through in vivo engineering targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets doi.org/10.1126/scienc… Carl June Haig Aghajanian #CellTherapy #CARTCell #TranslationalScience

#AdolescentBrain: #SexDifferences in the spatial organization of functional #Brain networks accentuated in association networks especially in frontoparietal & ventral attention networks doi.org/10.1192/bjp.20… #MentalHealth #TranslationalScience

Discerning underlying mechanisms linking loss in the methyltransferase DOT1L activity to #NeurodevelopmentalDisorders (#NDDs) doi.org/10.1093/brain/… #MentalHealth #Neurology #TranslationalScience

Developing biomarkers to differentiate between #Parkinsons disease (PD) and dementia with #LewyBodyDisease: Implications for #α-synuclein (aSyn) misfolding & aggregation doi.org/10.1002/ana.27… Alice Chen-Plotkin #NeuroDegeneration #Neurology #TranslationalScience

You’re Invited: Where Science Meets Art: ITMAT Artist-in-Residence Ceramic Showcase on 7/24 from 5-7 PM at the Institute for Contemporary Art in Philadelphia, PA! RSVP at instagram.com/upenn_itmat/

Penn Medicine #BioBank growing its impact: Discerning early aortic #aging from imaging data with links to adverse #CardiacRemodeling and poor #CardiovascularOutcomes ahajournals.org/doi/10.1161/CI… The Penn Medicine BioBank #PMBB #TranslationalScience