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Thrilled about our collaboration with Cris Mayor-Ruiz lab. This work identifies synthetic lethal vulnerabilities of cancer cells that exhibit widespread #resistance to #degraders! Congrats to Sergi Rafael and Dr. Carolina Sanchez (URSAchem) and all co-authors!

📢We are hiring! #PhDposition at Vall d’Hebron Institute of Oncology (VHIO) 🎯We aim to uncover novel patterns of chromosome instability in #cancer using 💻multi-omic analyses 🧬functional validations 💊to impact in patients My group▶️vhio.net/pf/sarcoma-tra… Apply▶️vhio.net/es/vhio-phd-op… Questions? DM or email!

A great day at the BIST-Barcelona Institute of Science and Technology Forum 2024! Congratulations to Dr. Antoni Riera and Dr. sara sdelci who presented their project EXPLODE-TNBC. This work aims to apply targeted protein degradation to find treatments for the elusive breast cancer type, Triple-Negative Breast cancer.

💊New drug reveals a key mechanism to overcome resistance to #ProteinDegraders. ✍️ Bárbara Barbosa Karen Sfyaki Ferran José Duran Sergi Rafael Cris Mayor-Ruiz URSAchem et al. 📰 Angewandte Chemie ➡️shorturl.at/gnFJY 📌doi.org/10.1002/anie.2… #IRBScience #TPD

🆕Chemical rewiring of ubiquitination by #degraders and their selectivity routes. ✍️Rory Whelan & Cris Mayor-Ruiz 📰🎂NatureStructMolBiol’s 3⃣0⃣th anniversary issue! 🔗shorturl.at/gmBIK 📌doi.org/10.1038/s41594… #IRBScience #TPD

En esta convocatoria de Cancer Grand Challenges Challenges, en Asociación Española Contra el Cáncer apoyamos a la Dra. Cris Mayor-Ruiz (IRB Barcelona) y su participación en el proyecto PROTECT para el desarrollo de tratamientos efectivos para cánceres infantiles. #investigandoencáncer ➡️contraelcancer.es/es/investigaci…

#IRBBarcelona scientist Cris Mayor-Ruiz to participate in the Cancer Grand Challenges team #PROTECT, to apply targeted protein degradation against various types of paediatric tumours. Asociación Española Contra el Cáncer is involved in this global funding initiative and supports this project, which will last

Our recent paper in collaboration with Dr. Cristina Mayor-Ruiz has made the cover of Angewandte! Congratulations to our PhD student/graphic design wizard, #Sergi Rafael and all the authors involved in its design!

#PCBCommunity | Cris Mayor-Ruiz, group leader del laboratorio de Degradación Dirigida de Proteínas y Descubrimiento de Fármacos del IRB Barcelona, gana el Premio 60 Aniversario Farmaindustria Jóvenes Investigadores. ¡Felicidades! 👏🔝 Farmaindustria #cancer

Our PhD student Sergi Rafael presented his work at IRB Barcelona as part of the Research Nodes Seminar series. He explained his exciting research in Proximity-induced Pharmacology and its application toward developing novel treatments for evasive cancers. Well done Sergi!

Day out with the group before cooling off for August, happy vacations!

Check out our work preparing 3,3-diarylallyl phthalimides as single diastereomers. we use this approach to synthesise various cyclopropylamines and achieve their highest enantioselectivities reported to date! pubs.acs.org/doi/full/10.10… Congrats to Martí Sidro (@Maarti164 ) et al!

La setmana passada vaig presentar la feina feta a URSAchem a la 1a Reunió de Química Orgànica SCQ. Va ser un plaer poder participar-hi i veure la química fascinant que fem al país!

Congrats to our PhD graduate Dr. Marina Bellido (Marina Bellido) and PhD student Marti Sidro (martichickpea) for their recent work in developing the p-stereogenic phosphane ligand, MAdPHOS, which provides outstanding enantioselectivities in asymmetric hydrogenation of enamides!

Our PhD student, Sergi Rafael presented his thesis, Heterobifunctional Molecules: PROTACS and beyond. From overcoming degrader resistance to rewiring ERF activity, Sergi discussed his work with fantastic animations. Congratulations Dr. Rafael!!

Another fascinating year of demonstrations by our group at the IRB Barcelona Open Day. Great to reach out to the community and show off the excitment of chemistry! Many thanks to IRB Barcelona for organising this fantastic event.