
Vytaute Boreikaite
@vboreikaite
PhD student with @lapassmore at @MRC_LMB & @Cambridge_Uni (@QueensCam @JesusCollegeCam)
ID: 1258383470423937027
07-05-2020 13:10:05
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102 Followers
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PolyA tails on eukaryotic mRNAs are added after co-transcriptional endonucleolytic cleavage of the pre-mRNA. Vytaute Boreikaite has now reconstituted specific and efficient 3ʹ-endonuclease activity by human CPSF with purified proteins. European Research Council (ERC) @MRC_LMB biorxiv.org/content/10.110…


Vytaute's Vytaute Boreikaite PhD work on reconstituting the activity of the human CPSF complex has now been published online 🎉. Genes & Development genesdev.cshlp.org/content/early/… (see previous thread for details)

Very excited to write this Outlook piece with Yoseop Yoon for Genes & Development highlighting the groundbreaking work from Elmar Wahle and Lori Passmore groups on reconstituting the human mRNA 3' processing in vitro! genesdev.cshlp.org/cgi/content/lo… genesdev.cshlp.org/cgi/content/lo… genesdev.cshlp.org/cgi/content/lo…

#Microsymposium2022 also features a #PhDworkshop, at the end of which one of the PhD candidate speakers will be selected for an #award Photo: Vytaute Boreikaite (@MRC_LMB), #workshop part 1 IMP GMI Vienna gmivienna.bsky.social Max Perutz Labs Vienna Vienna BioCenter #RNA #RNAbiology #symposium #PhD


And concluding #Microsymposium2022 with the #PhDworkshop prizes! 1st prize goes to Lisa Baumgartner from @juliusbrennecke's lab at IMBA! The two 2nd prizes go to Vytaute Boreikaite (@MRC_LMB) and @MakiGoesScience from our neighboring GMI Vienna gmivienna.bsky.social ! Congratulations to the awardees!


Work from Juan B Rodriguez Molina on the role of Mpe1 in mRNA 3' end processing is now out in Molecular Cell ! This was a team effort including Francis O'Reilly Holly Fagarasan Eleanor Sheekey Rappsilber laboratory European Research Council (ERC) @MRC_LMB


New work from Manuel Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. Cemre Manav @MRC_LMB European Research Council (ERC)

Fun times in the Passmore lab! Congratulations to Vytaute Boreikaite who has just completed her PhD!


Human mRNAs form globules in 3D and are prepared for export by the transcription-export complex. We are excited to share this and more mechanistic insights in our newest work, co-lead by the fantastic Belén Pacheco-Fiallos and Matthias Vorländer. rdcu.be/c9e0f (1/9)


Our work on Pol II dephosphorylation and its connection to transcription regulation and mRNA 3' end processing by the Cleavage and Polyadenylation Factor (CPF) is now out in Molecular Cell!