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.Steffen Massberg, Tobias Petzold, Zhang&co show that #neutrophils “pluck” intravascular #megakaryocyte extensions to drive #platelet production & promote cardiovascular disease authors.elsevier.com/sd/article/S10…

You reap what you sow: Neutrophils “plucking” platelets harvest prothrombotic effects dlvr.it/SfVLhG

A sharp commentary to our collaborative paper with Tobias Petzold & Steffen Massberg showing proplatelet "plucking" by #neutrophils l 🙏 Erinke & Udalova Lab - Genomics of Inflammation sciencedirect.com/science/articl…

Our amazing bear story is finally out in Science Magazine. In summary, we identified a mechanism with which brown bears avoid venous thrombosis during hibernation and could show that this thromboprotective mechanism also exists in humans. tinyurl.com/489wwvyc

Today in Science Magazine with Tobias Petzold we publish the fruit of >10 y of research. We discovered a new mechanism in bear platelets protecting against blood clots. It also exists in humans science.org/doi/10.1126/sc… (1/8)

Out today in Science: a shared mechanism that shields hibernating bears & long-term paraplegics from venous thrombosis! Thanks for the great collaboration Tobias Petzold, Johannes B Müller-Reif, @Cardio_LMU, DLR - English, NASA & the Scandinavian Brown Bear Project! science.org/doi/10.1126/sc…

Warum bekommen Bären im Winterschlaf und querschnittsgelähmte Menschen keine #Thrombose? Dieser Frage ging ein internationales Forschungsteam nach und entdeckte einen Mechanismus, der die Bildung von Blutgerinnseln verhindern könnte. mpg.de/das-paradoxon-…

A beautiful perspective from Mirta Schattner - on longterm immobility induced thromboprotection. ⁦Vincent Ehreiser⁩, ⁦Anne Dueck⁩ ⁦Johannes B Müller-Reif⁩ ⁦Ole Fröbert⁩ Check also: science podcast and ⁦News from Science⁩ science.org/doi/10.1126/sc…

Why do hibernating bears, despite prolonged immobility, not get venous thromboembolism? In a new study, scientists prioritize HSP47 down-regulation. I am most impressed with the team for sticking needles in hibernating brown bears!! 😲 science.org/doi/10.1126/sc… Science Magazine

MS-based proteomics is an indispensable tool to study proteins in non-model organisms. Read here to find out how we used it to find a new mechanism of thromboprotection in hibernating bears that is conserved in humans.

Macrophages mess with ❤️ rhythm ⚡️ transcriptomics and protein data describe 3-fold expansion of these leukocytes in patients with atrial fibrillation. Among the top expressed genes: osteopontin (SPP1), catalyzing atrial fibrosis and inflammation ❤️‍🔥 science.org/doi/10.1126/sc…

Multi-Omics Factor analysis of blood #multiomic data, including single cell #transcriptomics, for individuals with either acute or chronic #coronary #syndrome identifies immune cell signatures that correlate with treatment outcomes. nature.com/articles/s4159…

Happy to announce that our new lab in Berlin Deutsches Herzzentrum der Charité is recruiting! We are offering PhD and postdoc positions. Join our exciting journey to discover and to translate novel mechanism in thromboinflammation - within an fantastic team -apply: karriere.charite.de/en/job-vacanci…

We are delighted to share our latest findings today in nature. We describe cardiogenic regulation of sleep after cardiac injury. “Myocardial infarction augments sleep to limit cardiac inflammation and damage” nature.com/articles/s4158…

Long-term FXa inhibition induces anti-thromboinflammatory proteome signatures in platelets, improving infarct size after myocardial infarction and stroke. jthjournal.org/article/S1538-…

#2 of our Top 10 Altmetric Papers of 2024 Countdown! 2️⃣ Long-term FXa inhibition attenuates thromboinflammation after acute myocardial infarction and stroke by platelet proteome alteration 🔬 Breakthrough in managing thromboinflammation. 📅 Published: 16 Nov 2024 🔗