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If you have spare $40,000 you can have a universe in your pocket. The largest simulation of the Universe is about to be published sciencealert.com/researchers-ha… Original article arxiv.org/abs/2007.14720

A comprehensive study using large amounts of data resulted in an interesting and unexpected finding. Glad to be involved in this project.

Very excited to announce that our work has been published!

We have decided to retire the Pfam website in October. But all the functionality and data is available in InterPro. More info in our blog xfam.wordpress.com/2022/08/04/pfa…

Congratulations to Jiawei Xing for his first paper!!! Showing that bacterial Photoactive Yellow Protein is an evolutionarily novel, highly specialized PAS domain, which keeps acquiring novel sensory functions, as we speak. Vadim Gumerov journals.asm.org/doi/10.1128/jb…

Proud to be selected!

New insights into the nature of voltage-gated calcium channels and the role of Cache domains were recently published tandfonline.com/doi/full/10.10… #channels #eukaryotes #gabapentine

Tracing evolution of individual amino acid positions in a serine/threonine kinase, we deduce whether a variant seen in humans is damaging or benign. With experimental validation in an animal model by Stas Shvartsman lab: biorxiv.org/content/10.110…

A broad class of receptors found in various signal transduction systems bind biogenic amines through a conserved motif. The receptors originated from the universal amino acid receptor.

PAS domains are almost everywhere. Check out the entertaining story of these fascinating domains

We have released a new version of the MiST database. Check out mistdb.com #database #Bioinformatics #protein #Biology

Transmembrane transcription regulators have been thought of as a rare phenomenon. In the recent study Lucas Demey (Victor DiRita lab) and I (Zhulin Lab; Jiawei Xing contributed) uncovered their unexpected diversity and abundance in Bacteria/Archaea journals.asm.org/doi/10.1128/sp……

Gaining access to nutrients as the primary benefit from #chemotaxis. Please read our recent article in Current Opinion in Microbiology on this matter. Miguel_Matilla Jose A. Gavira -Gavi- BLAST Meetings CSIC sciencedirect.com/science/articl…

Nature has already made mutations; we just need to analyze them... Evolutionary history of MEK1 illuminates the nature of deleterious mutations | PNAS pnas.org/doi/10.1073/pn…

PAS domain proteins are involved in various cellular processes in all branches of life and play an important physiological role in the human body. A work by Jiawei Xing presents a multifaceted analysis of the PAS domain superfamily science.org/doi/10.1126/sc…

Purines are crucial for making nucleotides and nucleic acids. We identified a fascinating group of receptors sensing purines and performed a comprehensive analysis of them. Krell Laboratory Zhulin Lab Elizabet Monteagudo Cascales Mati @gavirius Miguel_Matilla disq.us/t/4pmf7gu