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Excited to share our new paper in Orli Bahcall! Can a mutation really hit the same place twice? We found biallelic mutations across 2,658 cancer genomes that contradict the famous infinite sites assumption and highlight the processes behind them: nature.com/articles/s4158…

🎉We’ve officially released ASCAT version 3! You can now run ASCAT on sequencing data with improved copy number calling and brand-new quality control metrics. See the full list of features and download ASCAT v3 here: github.com/VanLoo-lab/asc…

We are delighted to announce Dr. Jonas Demeulemeester as a new group leader in the VIB Center for Cancer Biology as of today where he will establish his Laboratory of Integrative Genomics. Welcome Jonas Demeulemeester at CCB_VIB_KUL!

We’re looking for #postdocs interested in #cancergenomics to join our lab at MD Anderson Cancer Center – An exciting opportunity to lead large-scale studies of #tumorevolution: mdanderson.org/research/depar…

Fantastic work linking somatic mutation rates with lifespan across mammalian species, allowing us to make sense of the lack of relationship between body size and cancer incidence.

Tumor samples vary in purity and ploidy, both of which confound DNA methylation measures from bulk sequencing. We developed CAMDAC to clean up this signal. Here's our extended preprint with new insights from applying CAMDAC to TRACERx lung RRBS data: biorxiv.org/content/10.110…

Total mRNA expression in tumor cells is an important, but so far elusive, biomarker. This elegant piece of team science establishes the mathematical relationships between copy number, purity and gene expression in tumor cells. Proud to have been part of this great team!

Registration is now open for our Somatic Evolution and Tumour Microenvironment (SETM) symposium, where discussions and talks will focus on improving our understanding of cancer evolution. 📅 12 December 2022 🎟️ Free to attend online or in person ow.ly/4eqE50LgyVK

How can we track cancer evolution using somatic copy-number alterations while considering whole-genome doubling events? With MEDICC2, now out in Genome Biology! schwarzlab.de/news#medicc2 doi.org/10.1186/s13059… bitbucket.org/schwarzlab/med…

World class TRIUMPH mentors are hiring post-doctoral fellows MD Anderson Cancer Center: Jennifer Wargo MD Stephanie Watowich Raghu Kalluri Cullen Taniguchi, MD Peter Van Loo @tcellsrus Wenyi Wang Anil Sood Pawel K. Mazur Li Ma, PhD Albert Koong, MD PhD Scott Kopetz George A. Calin Apply: bit.ly/3hDLMXj

Today, @nature and natureMedicine are proud to publish amazing new insights into lung cancer evolution from the #TRACERx consortium. Updated collection: nature.com/collections/ha… Great author threads👇

Exciting find in our #OralCancer study! 🧬 Brush biopsies prove promising, reflecting 90% of somatic changes vs. tissue biopsies. 🩸 Highlighting their potential in understanding tumor evolution. #CancerEvolution biorxiv.org/content/10.110…

NEW REVIEW ARTICLE Nature Cancer – “Aneuploidy and complex genomic rearrangements in cancer evolution” by Peter Van Loo #TobyMBaker #SaraWaise #MaximeTarabichi. Read it here👇 nature.com/articles/s4301… rdcu.be/dxoLb

🚀 Excited to share our latest research! We developed GRITIC, a novel method for timing genomic gains using bulk WGS data. Our findings reveal non-parsimonious evolution and increased chromosomal instability post-genome doubling in tumors. aacrjournals.org/cancerdiscover… #cancergenomics