Plant polygalacturonase structures specify enzyme dynamics and processivities to fine-tune cell wall pectins buff.ly/3BOtedu ASPB #PlantSci

Loop dynamics and the evolution of enzyme activity nature.com/articles/s4157… A Review by Marina Corbella, Gaspar P. Pinto & Shina C. L. Kamerlin Caroline Lynn Kamerlin 🇺🇸🇬🇧🇸🇪🇮🇷 ☀️ 🇪🇺🦓, @corbellamorato, Gaspar P. Pinto, GT (Bio)chemistry, @UUBiochem

My brain feels intrinsically disordered today 🧠

Pleased to share our most recent publication in collab with the Pelloux Group (University of Picardie Jules Verne), in The Plant Cell. 🌱 My first, first author paper and the core of my Master's research - it's a special one 🥳 doi.org/10.1093/plcell…

Earlier this year, we published a paper elucidating the specificity of a pectate lyase in the International Journal of Biological Macromolecules. Another collab with the Pelloux Group! 🌿 doi.org/10.1016/j.ijbi…

Presented a poster at my first in-person science conference in Wollongong, Australia! 🦘 Thanks to the Association of Molecular Modellers of Australasia and UOW for hosting, and for awarding me a travel award 🥳 #AMMA_MM2023

I presented a comparison of two seemingly similar coarse-grained molecular dynamics models of a large intrinsically disordered protein. This work is part of an ongoing collab with Mikayel Aznauryan and Cameron Mackereth groups at UNI Bordeaux 🤗

Fun times at #AMMA_MM2023 learning all things science, hunting kangaroos (🦘!!) and meeting new people including Alex Holehouse and Lipi Thukral 😁 Jordan McIvor Davide Mercadante

Vanessa Ung Alex Holehouse Jordan McIvor Davide Mercadante I have a nice one too? Had a blast

Back by popular demand for 2024: The #Oscars as things seen in science. First up, Sam Rockwell as a failed PCR

Disordered regions of human eIF4B orchestrate a dynamic self-association landscape biorxiv.org/cgi/content/sh… #biorxiv_biophys

Excited to share our latest preprint! First co-authoring this one with Bikash Chandra Swain and Pascale Sarkis, representing the Mercadante Group Davide Mercadante in a collaboration with Mikayel Aznauryan and Cameron Mackereth - have a read!

In this work with Jordan McIvor(!), we looked at how short vs long distance electrostatics tune the ensemble of phosphorylated NCBD. We find that empowering a switch⚡btw long & short phosphate interactions can tune binding-competent NCBD conformations..👉pubs.acs.org/doi/10.1021/ac…

Thanks to all authors and particularly the spear-headers Bikash Chandra Swain Pascale Sarkis and Vanessa Ung

So exciting to our collaboration officially online! Thanks to everyone involved, congrats all 🥰

This work also involved an exciting and time-zone spanning collaboration with Davide Mercadante and Vanessa Ung from the University of Auckland, which introduced me to many aspects of coarse-grained molecular simulation, and I look forward to the next steps!

Bikash Chandra Swain, Pascale Sarkis, Vanessa Ung, Davide Mercadante, Cameron Mackereth and Mikayel Aznauryan reveal how the intrinsically disordered region of eIF4B governs its transition from monomers to oligomers and condensed droplets. nature.com/articles/s4146…

Our latest preprint is now available on BioRxiv! Have a read at: biorxiv.org/content/10.110…