We enjoyed a great round of talks by Alberto Ciccia (Columbia), Lee Zou (Duke), Dr. Agnel Sfeir (MSKCC), and Ranjit Bindra,MD/PhD (Yale), plus our trainees Arindam Datta and Azrin Jamalruddin at yesterday’s PCGI Mini Symposium on "Targeting the Damage Response"

Exciting results! Using AID-Degron system, Dr. Yimeng Zhu found that Ku suppresses RNA-mediated innate immunity to accommodate Alu-expansion in primates - solving the misery of Ku essentiality in human cells! Thank@chaolinzhang⁩ biorxiv.org/content/10.110…

New from the Brian Liau Lab, two papers in nature that reveal a chemical-genetic convergence #chemtwitter #CancerResearch

Very happy to have participated to this fantastic work by Brian Liau and Ning Zheng, which sheds an electron microscopy light on the mechanism of KBTBD4 mutant recognition of CoRest. Substrate diversification of E3s by mutations nature.com/articles/s4158…

Seeing is believing! Our sequel now shows precisely how midnolin delivers substrates directly to the proteasome by repurposing established proteasomal subunits, a process critical to suppress multiple myeloma via IRF4 degradation. biorxiv.org/content/10.110…

Check out our nature review with Tiannan Guo Guomics and Judith Steen Judith Steen on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…

Our paper on bacterial clippases is now out in Molecular Cell. These really interesting enzymes can make deconjugation of #ubiquitin irreversible. Thanks to Universität zu Köln and Cologne Crystallisation facility for support. cell.com/molecular-cell…

Review from our lab out today: "Roles for the 3D Genome In the cell cycle, DNA replication, and double strand break repair." Written by Dr Kate Giles, with her co-supervisor Phillippa Taberlay and collaborator Mat Jones. frontiersin.org/journals/cel...

Thank you to Christina Woo of Harvard University for presenting such a data-packed, standing-room only seminar in Molecular Therapeutics Molecular Therapeutics Initiative UC Berkeley this week! Awesome work!!!

We are excited to report work from PCGI Director Roger Greenberg together with Elton Zeqiraj and Joe Salvino on the discovery of BIRSC deubiquitinating enzyme inhibitors for inflammatory indications rdcu.be/edRwF.

Thanks for enriching it, Dan ;-)

Our PCA-N method with neutralization step enables direct enzymatic digestion, doubles proteome depth from 5µL neat plasma, and scales to 10K+ sample preps/day. Democratizing plasma proteomics with validation across 50K measurements. On bioRxiv! biorxiv.org/content/10.110…

Congratulations to everyone involved including Eimear Lagan, Richard Phillips, Adrian Bracken, Gerry Brien and others at TCD Genetics & Microbiology, Institute of Genetics and Cancer & @UPenn! Read our web story here: edin.ac/4jeAkLw

Excited to share our publication out in Science today! We define a role for the CST complex in DSB repair pathway choice. This study was conducted in close collaboration with Patrick Sung’s lab. Congratulations to Michelle Swift and all other authors! science.org/doi/10.1126/sc…

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested, closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationIni…

Excited to share our discovery of ACBI4: VHL PROTAC degrader of KRAS(on) mutant e.g. G12R. High ternary-complex cooperativity to the rescue! VHL Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-loaded KRAS(on) Alleles | ChemRxiv - go.shr.lc/4efUF2s

With this new funding, we’re hiring PhDs and #postdocjobs Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.

🚨 New from The Gilbertson Lab CRUK Cambridge Institute in Cancer Cell A graph-embedding pipeline reveals how gene co-expression changes during treatment, enabling the design of powerful combination therapies for brain & breast cancers. 📄Read more: cell.com/cancer-cell/fu… #CancerResearch #RECODR

Interested in inherited chromosomal instability syndromes and DNA repair? We are looking for an enthusiastic person to join the Stewart lab at the University of Birmingham as a senior technician. If you are interested, please have a look at the job advert: jobs.ac.uk/job/DPH515/sen…