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So excited to teach ⁦⁦LIVEKellyRyan⁩ and viewers #HandOnlyCPR tomorrow! It's easy and only 2 steps! #savealife #heartmonth ⁦NewYork-Presbyterian⁩

Rapid availability of organs in the new heart allocation system improved the incidence of transplant and lowered the mortality risk in temporary MCS pts. What about recovery? New collaborative study from Columbia and Utah HF teams published @jaccjournals jacc.org/doi/abs/10.101…

How has the new heart transplant allocation system affected the likelihood of #CHF transplant candidate recovery? Drs. Veli Topkara, Stavros George Drakos, et al. present their work in #JACC to help answer this question: bit.ly/35HZv9w #CardioTwitter #FunctionNotFailure

Our NEW meta-analysis on Dx accuracy of #POCUS in acute heart failure in The American Journal of Cardiology 🙏to co-1st author Meghan Pooja Jairam, MD, co-authors @ChunHanLoMDMPH Nicholas Chiu, MD MPH Adam Alhassan MD, MPH & awesome mentor Veli Topkara ajconline.org/article/S0002-…

Thank you to all collaborators/co-authors for their hard work on these companion articles addressing this topic from bench to bedside. Manreet Kanwar Palak Shah Eleni Tseliou Khue Ton Omar Wever-Pinzon Lavine Lab Veli Topkara Josef Stehlik Anju Bhardwaj MD FACC @ersied727 UofU Nora Eccles Harrison CVRTI

Our center’s experience on the study of CAV post OHT with myocardial flow assessment with cardiac PET now in JACC Journals Novel insights on long term risk beyond epicardial CAV Outstanding work led by #KevinClerkin @NYPCUCVI Link: jacc.org/doi/10.1016/j.…

🔥off the press now Nature Cardiovascular Research, Rad regulation of calcium channels in beta adrenergic modulation rdcu.be/cZCvW. Honored to collaborate w/Dr Steven Marx, leading the path to new therapeutics for cardiac contractility! @NYPCUCVI ColumbiaCardiology Columbia Medicine #CardioTwitter

Research|Arianne Papa et al Steven Marx show that phosphorylation of 4 residues in Rad, a #calcium channel inhibitor, is required to mediate the βadrenergic #cardiac #FightOrFlightResponse. Columbia Medicine #ColumbiaCardiology #NYP nature.com/articles/s4416…

Honored to publish our studies identifying the mechanism underlying sympathetic nervous system regulation of calcium channels and heart contractility. Finally solved after ~50 years! Nature Cardiovascular Research rdcu.be/cZCvW ColumbiaCardiology Columbia Medicine #arrhythmia #EPeeps

INTERMACS analysis shows moderate to severe residual MR is present in 18.8% of #LVAD supported patients. Residual MR is associated with RV failure, renal failure, and a trend toward increased mortality. Rashmi Jain Lauren K. Truby Veli Topkara 🔗: jhltonline.org/article/S1053-…

Genome editing to restore heart function of dilated cardiomyopathy in experimental model science.org/doi/10.1126/sc… Science Translational Medicine

Durable #LVAD use ~30%⬇️ in new vs old 🫀allocation era, with similar waitlist results in patients bridged w/HM3. Predictors of post-tx mortality: old age, ischemic HF, ⬇️functional status, ⬆️creatinine, pulmonary HTN, obesity Veli Topkara Nir Uriel, MD MSc 🔗jhltonline.org/article/S1053-…

Excellent review demonstrating albuminuria as an independent predictor of outcome in HF. We showed that albuminuria is a predictor of renal replacement therapy after LVAD implantation irrespective of eGFR Circ: Heart Failure. Important marker but often overlooked. ahajournals.org/doi/10.1161/CI…

Excited to share new research from our laboratory led by xhliao and Peter Kennel on Epigenetics of Heart Failure, Recovery with LVAD, and discovery of LINC00881 as a novel target. Grateful to our collaborators ReillyLab, Nir Uriel, MD MSc, @GVNLab, Steven Marx. insight.jci.org/articles/view/…

Effect of mechanical unloading on genome-wide DNA methylation profile of the failing human heart: buff.ly/3Z6cPeC Veli Topkara Columbia Medicine #Cardiology

Exciting talk on #Genetic changes implicated in #LVRecovery by Veli Topkara #THT2023 Did you know that #LVRecovery genes include Reversible, persistent and new recovery genes ? CardioNerds

Today in #EHJ, we present the 1st time an AI model has outperformed radiologists in detecting cardiac pathology. ❤️‍🩹 Potential screen for #CHF w/ CXRs 🌁 Trained Columbia Medicine validated Stanford AIMI 🩻 Entire dataset (75k CXRs) released European Society of Cardiology Journals shorturl.at/cOT16

#ResearchLetter: Augmentation of cardiac contractility by phosphodiesterase inhibition requires phosphorylation of the Ca2+ channel inhibitor Rad and subsequent increased Ca2+ entry. ahajournals.org/doi/10.1161/CI…

Congratulations Donna Mancini, well deserved recognition for #1 transplant cardiologist.

Advanced Heart Failure & Transplant Program at the University of Wisconsin – Madison is searching for outstanding HF cardiologists to join our academic faculty and expand our clinical and research programs. Link: nejmcareercenter.org/job/820491/adv…