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Now add #AI and structure-based drug discovery for screening 10X faster, 100X more potent , 1000X less cost for new potential small molecule drugs vs #Parkinson's disease nature.com/articles/s4158… Robert Horne Cambridge University KnowlesLab Cambridge Vendruscolo Lab

New research from Robert Horne KnowlesLab Cambridge Vendruscolo Lab & colleagues presents a machine learning approach to identify small molecule inhibitors of α-synuclein aggregation, a process implicated in #Parkinsons & other synucleinopathies nature.com/articles/s4158…

Press summary associated with this research: cam.ac.uk/research/news/…

🎯Excited to share a new article about our #Twin4Promis partner, Michele Vendruscolo and his incredible team Vendruscolo Lab from the Cambridge Chemistry ! 🌟 Learn more about their pioneering work in protein folding here: rb.gy/s2z0r1

Outcome of a great collaboration with Vendruscolo Lab is now published! Well done Ewa Andrzejewska.

The man, the myth, the legend: Samuel Dada just published a paper with Vendruscolo Lab & Cambridge Chemistry colleagues demonstrating a possible therapeutic route for #Parkinsons based on the inhibition of alpha synuclein protein aggregation within condensates nature.com/articles/s4146…

Starting the 2nd day of #ML4NGPmeeting with an inspiring talk from Michele Vendruscolo Vendruscolo Lab on #drug design for targeting disordered proteins #IDPs and inhibit #aggregation within condensates 🫧 What an amazing start👏

Check out the latest episode (no.9) of the Phase Space Invaders podcast 🎙️ where Prof. Michele Vendruscolo talks about preventing protein misfolding, AI in drug discovery 💊 and the importance of good mentorship 🧠 Access all episodes ➡️ bit.ly/3QO4EBx Vendruscolo Lab

Very excited to share our work in Nature Communications! We show that a-synuclein oligomers and fibrils form by secondary nucleation on existing fibril surfaces nature.com/articles/s4146…

Our latest paper by Catherine Xu - secondary nucleation is the source of both oligomers and fibrils in Parkinson's associated a-Synuclein aggregation. Fantastic collaboration with Linse lab SpillantiniLab and Vendruscolo Lab nature.com/articles/s4146…

New AI predicts how proteins behave inside cells, starting as small droplets and condensing into larger ones. This tool predicts how proteins come together using data that are extremely challenging to analyse traditionally. PNASNews Vendruscolo Lab ch.cam.ac.uk/news/new-ai-pr…

Just on my way back from Lisbon from the TWIN2PIPSA 🇪🇺 Protein Biophysics & Self-Assembly workshop on Bioimaging and Protein Interaction. Thanks Cláudio Gomes Lab - Protein Misfolding in Disease and Vendruscolo Lab for inviting me to present our work on alpha-synuclein phase separation in cells!! #LLPS #synuclein #science #Parkinson

#ML4NGPtalks🎙️ How can #COSTactions like #ML4NGP drive #research and #innovation? Find out in our first talk with Michele Vendruscolo as he dives into the future of #MachineLearning in #proteinscience. Watch now! 🎬 youtu.be/ALhG6U6M3vg COST Vendruscolo Lab

A touching tribute by Robinson Research Group & Colin Robinson honoring the remarkable life and contributions of Professor Sir Christopher M. Dobson, F.R.S. A visionary scientist and outstanding mentor: royalsocietypublishing.org/doi/pdf/10.109…

Grateful for the great turnout at my seminar at Cambridge Chemistry on chaperones and protein aggregation in neurodegeneration 🧠 It was great to connect, discuss research and explore new collaboration opportunities with so many of you! KnowlesLab Cambridge Vendruscolo Lab TWIN2PIPSA 🇪🇺 Protein Biophysics & Self-Assembly

Can deep learning methods trained on folded proteins effectively predict the structural ensembles of disordered proteins? Cambridge University Cambridge Chemistry Vendruscolo Lab "AlphaFold-Metainference: Prediction of Structural Ensembles of Disordered Proteins" • A new development

🔥Very excited to see our work just published in Science Advances! doi.org/10.1126/sciadv… "Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments". Grateful for the collaboration with Faidon Brotzakis, Michele Vendruscolo, Vendruscolo Lab.

It is always nicer collaborating than competing. In Biophysical Journal we join the forces of Ventura's Lab Switch Lab Vendruscolo Lab Università di Padova & Università di Firenze #Aggregation #Predictors to study #Amyloid #Structure Lead by Fabrizio Chiti portlandpress.com/biochemj/artic…

🚨Checkout our latest work in Science Advances on characterising Ab42 Alzheimer's disease brain derived amyloid fibrils structural dynamics using #MEMMI 🖥️ and #CryoEM 🧊data. Work with MariaMilanesi Michele Vendruscolo Vendruscolo Lab Cambridge University Biomedical Sciences Research Center Al. Fleming .

New research from Michele Vendruscolo Vendruscolo Lab & collaborators compares the phase behavior of four α-Synuclein isoforms & finds stark differences between them in their propensities to undergo phase separation & aggregation; #Parkinsons science.org/doi/10.1126/sc…