🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Research| Maddeb et al. show that while #HFpEF presents normal-looking contraction, the muscle looks abnormal, with disrupted contracting proteins, mitochondria and excess fat, particularly in the most obese patients. 👉rdcu.be/dPlJ7

🚀 Thrilled to share our new publication in Nature CVR! We revealed the crucial role of a newly described APOE+ valve interstitial cell subtype in human valve remodeling. Huge thanks to our amazing collaborators! 🙌 Jason Spence Ya-Wen Chen YutzeyLab Simon Miao

Research| Shetty et al report that a favourable #cardiovascular risk factor profile may partially offset the risk of #HeartFailure and atrial fibrillation among carriers of high-proportion spliced-in Titin truncating variants. doi.org/10.1038/s44161… 👉 rdcu.be/dPNgq

Research| Sarig & Tzahor et al. show that the #MultipleSclerosis drug, glatiramer-acetate, improves cardiac function and reduces scar area in rodent models of acute #MyocardialInfarction and ischaemic heart failure. doi.org/10.1038/s44161… 👉 rdcu.be/dR9YV

🚀Kick off 2025 with exciting studies of #lymphatics🚀 🔬 Centrifugal vs. centripetal origins of LECs oliver stone nature.com/articles/s4416… 🧬 Unveiling lymphatic smooth muscle cell identity Padera Lab cell.com/developmental-… Scott Zawieja elifesciences.org/reviewed-prepr…

❤️Our February issue is out❤️ Discover how neonatal heart regeneration extends to the conduction system, a new kinase controlling atherosclerotic plaque development, vascular smooth muscle cell phenotypic switching in aneurysms, and more! nature.com/natcardiovascr…

Research| Maatz, Lindberg, and colleagues identify molecular alterations and immune response changes in endomyocardial biopsies from patients with #myocarditis following #COVIDー19 infection, anti-COVID-19 vaccination, or non-COVID-related causes. 👉rdcu.be/ea3Ic

We are super excited to announce our Nature Conference 'Engineered models of human disease', which will take place in Belgrade, Serbia, 28th-29th October 2025! Join us to discuss the design of human-relevant disease models! Nature Conferences Sign up here: go.nature.com/41isWrM

Research| Secco et al. present the CycleTrack genetic tracing method to visualise cardiomyocyte turnover in neonatal and adult mice, after myocardial infarction, and upon pro-regenerative stimulation. doi.org/10.1038/s44161… 👉rdcu.be/ecVZp Mauro Giacca

Perspective| Fuster, Sanz & Castellano review the need for a cardiovascular polypill, the evidence supporting its benefits, and the challenges impeding its widespread implementation. doi.org/10.1038/s44161… rdcu.be/edr5d

Pumpaj!

"The Australian is the sixth person globally to receive the device, known as BiVACOR, but the first to live with it for more than a month."

Check out this interesting Bioengineering conference organized by Nature Conferences Nature Reviews Bioengineering Nature Communications Nature Materials Nature Biomedical Engineering and Nature Cardiovascular Research and register!

Research| Li et al. show that maternal exposure to a Western-type diet can accelerate atherosclerosis in adult offspring, revealing how AP-1-mediated chromatin dynamics in fetal endothelial cells induce inflammatory memory through 27-hydroxycholesterol. rdcu.be/edUAd

Research | Cantu et al. identify the common and unique transcriptional regulatory networks in the endothelium of six different organs across development and show that these same transcriptional regulators can reprogram endothelial function in vitro. 👉rdcu.be/eet6U

Research | Fan, Zheng, Zhan, Xu, Liu et al. reveal that the RNA-binding protein ARID5A drives inflammaging through the NF-kB-TBK1 pathway, and inactivating myocardial ARID5A attenuates cardiac senescence and functional decline. doi.org/10.1038/s44161… rdcu.be/ej7ww

Research | Ling, Liu, and colleagues introduce MSR, a multiscale recursive algorithm that enhances cardiac microscopy for precise cardiovascular signal extraction, and validate the approach in vitro and in vivo. doi.org/10.1038/s44161… rdcu.be/elnFv

Research| Sadhu et al. identify and functionally validate ferredoxin-1 (FDX1) as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations. Nilanjana Sadhu LKCMedicine Research LKCMedicine doi.org/10.1038/s44161… rdcu.be/el1Xr

Research| Adamopoulos, Rovas et al. show that high regional wall shear stress correlates with fibrosis and left atrium electrical scarring in patients with atrial fibrillation, providing insight into the development of fibrosis. doi.org/10.1038/s44161… rdcu.be/emh6y