🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

(1/14) Excited to share our new work on ZNF143/ZFP143 by Domenic Narducci ZNF143 has been widely reported to be a general loop factor Instead we and deWitLab in a companion preprint show that ZNF143 is a TF with no loop function: biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Kickoff session for #Icte2024!

@sophie_lanciano (Gael Cristofari lab) uses clever cas9-guided ONT targeted sequencing to uncover principles underlying differential methylation of young L1 loci and effects on their local genomic environment. Great work and great talk! #ICTE2024 cell.com/cell-genomics/…

Back from the International congress on transposable elements meeting 🧬, I’m delighted about all the discussions and amazing people I met during these past few days 😄 Thanks to everyone for such great moments!!! Cherry on top, I received one of the three ‘best poster awards’ 🥳 #ICTE2024

Happy to share our review on viral genomics, where we discuss different methods to sequence viral genomes in a range of research and applied environments. Viral genome sequencing methods: benefits and pitfalls of current approaches portlandpress.com/biochemsoctran…

Pleased our study led by Gabriela O. Bodea of L1 activity in mouse parvalbumin (PV) interneurons has now been published Nature Neuroscience nature.com/articles/s4159… Props also to Juan Manuel Botto eugeniaferreiro Francisco J S-L Anthony Hannan + all the authors A brief recap 🧵👇 1/n

I am thrilled to see my first postdoc paper published in NatureStructMolBiol! 🌟🧠🧬 “Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease” nature.com/articles/s4159… 1/n 🧵

🎉Our paper quantifying how RNA flows across subcellular compartments is published! 🎉 Read more in the preprint thread ⬇️ The paper contains an improved analysis of RNA flow rates and new collaborative work on DDX3X with @stephenfloor authors.elsevier.com/a/1jMoV3vVUPRm… Molecular Cell

Looking for an exciting #PhD project in #molecularBiology? How about this question: what determines a gene's end? Most human genes have alternative ends, the choice of which is important for health and disease. Yet we still don't understand how this choice is made!

I just wrote a review on transcriptional regulation and I want to talk about something that has been bothering me for 5 years, which ended up changing how I think about science in general. A brief thread: authors.elsevier.com/sd/article/S09…

I happily wrote a Preview for the recent HUSH2 story Molecular Cell from the Tchasovnikarova lab Preview: tinyurl.com/5n6jrwut Article: sciencedirect.com/science/articl… The HUSH-HUSH2 link from L1 transcription to innate immunity could complicate efforts to target L1 in disease.

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…

Excited to share that our paper cell.com/molecular-cell… got the cover of the new issue of Molecular Cell. Extra cool that this is a photograph taken by the first author Nancy De La Cruz, a super-star research assistant and post-bacc who just started grad school UTSW Graduate School of Biomedical Sciences

I am looking for a motivated PhD student who is interested in understanding the fundamentals of gene regulation. They will be working directly with me on a DECRA funded project (scholarship guaranteed for domestic students). DM me if you know of anyone interested, including you

Looking forward to this! Thanks a lot for having me jackson hoffman FragileNucleosome

I am excited to share our review, published online today Nature Reviews Molecular Cell Biology. Pilong Li, Gaofeng Pei, Heankel Lyons, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). nature.com/articles/s4158…

Suuuuuuuper excited to see our work on the transcriptional dynamics of TEs across mammalian embryos finally out on Cell ! Short version: from rabbits, to cows, to pigs, to mice and even monkeys... TEs of all classes and ages are transcriptionally activated at ZGA ⚡

Tonight I found out that the NSF math postdoctoral fellowship I applied for is being deleted because it does not comply with Trump’s executive orders on DEI in the federal government. I’m going to answer some FAQs and share some thoughts about this ordeal in this thread 1/n

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. cell.com/cell/fulltext/….