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Cell experiments unveil how a potential therapeutic target coordinates cell migration, bioluminescent sensors reveal how molecules called WNTs bend a receptor-effector complex, and more in this week’s issue of #ScienceSignaling. scim.ag/286

A really cool paper (science.org/doi/10.1126/sc…) where Viktoria M S Kjær and Mette Rosenkilde describe arrestin independent internalization of GPR183, and we provide MD simulations. As an added value the article is featured on the cover of Sci Sig:).

Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization pubmed.ncbi.nlm.nih.gov/37014928/?utm_… #GPCR #signaling #pharmacology

📰Publication announcement📰 This week in Science Signaling we show that #GPCR #GPR183 internalizes independently of #arrestin, but rather utilizes a mechanism involving #caveolin. Arrestins, though, are crucial for migration mediated through the receptor. science.org/doi/10.1126/sc…

Thank you to Tomek for the very nice graphics that put us on the online cover

Researchers have discovered how the #GPCR GPR183—a therapeutic target in cancer and inflammation—coordinates #chemotaxis, which could facilitate efforts to target this receptor or other GPCRs in disease. UCPH Healthscience Mette Rosenkilde #Biochemistry scim.ag/2av

Scientists have made new discoveries about how a G protein–coupled receptor coordinates cell migration in response to stimuli, which could facilitate future efforts to target this receptor or other #GPCRs in inflammation or cancer. @SciSignal #Biochemistry scim.ag/2gs

During my Master's I worked in the lab of Deyang as a lab assistant. Now he just published his results in Nature. Big congrats on the achievement!

Really pleased to see this excellent review of THE most important viral protein family, VIROPORINS (😉) published by British Pharmacological Society brjpharmacol.org Great pleasure to work with Mette Rosenkilde, Viktoria M S Kjær, Birthe B. Kragelund and Kira Devantier on this. bpspubs.onlinelibrary.wiley.com/doi/10.1111/bp…