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#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance Here - in Science Advances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation. science.org/doi/10.1126/sc… More below 👇🏿

Very nice study by Pietro Zara and Elia Sechi !

Thanks to all the coauthors Mayo Florida AutoImmune Neurology Group Alberto Vogrig French Reference Center for PNS and AE Divyanshu Dubey Merkler lab Neuroimmunology Clinic Barcelona Bogdan Draganski Anne-Katrin Pröbstel and all the x-less ones !

The city where I was born😀 always a nice and relaxing walk!

Our latest study reveals a pathogenic role for neuronal pSTAT1 in autoimmune encephalitis (AE). link.springer.com/article/10.100… These findings suggest JAK-STAT1 inhibitors may hold therapeutic promise for AE-associated epilepsy (AEAE) reviewed here Nat Rev Neurology nature.com/articles/s4158…

Delighted to share Dinoto et al study on late onset MOGAD (50 yrs or more) ➡️ Accounts for 25% of MOGAD ➡️ Optic neuritis dominates & often misdiagnosed as ischemic (NAION or temporal arteritis) ➡️ Outcomes favorable & similar to other age groups 👇 neurology.org/doi/10.1212/WN…

⏳ Looking forward to the upcoming Queen Square Basal Ganglia Club Meeting on Neurogenetics of Movement Disorders with Prof. Valente from Università di Pavia & Prof. Klein from Universität Lübeck. NHNN, May 21, 4 PM. All welcome. Please RT Kailash Bhatia, Clinical and Movement Neurosciences @ UCL IoN MovementDisordersUCL UCL Queen Square Institute of Neurology

Just published 👉 A NEWLY updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote 🧠🔥 Why is this paper so important ? 1/

Want to find your place in translational research? Here’s how😉

Hirano et al. define a novel neurological disease spectrum involving the LGI1–ADAM22/23 pathway, identifying ultra-rare biallelic LGI1 variants in developmental and epileptic encephalopathy, and a biallelic ADAM23 variant in lethal neonatal epilepsy. tinyurl.com/4cpc48fy

Meningitis as a novel phenotype of MOGAD. Important study with practical implications in the ddx with infectious meningitis by Albert Aboseif Eoin Flanagan et al

Thrilled to be back in Lyon, where I first learned Neuroimmunology from Prof. Honnorat and his amazing team. Looking forward to presenting on treating epilepsy in autoimmune encephalitis (AE)! 😀

⚠️ Up to 1 in 4 patients with anti-NMDAR encephalitis relapse during recovery! 🧠 This study dives into why, who’s at risk, and how immunotherapy may help. 💉🔍 #NeuroTwitter #Encephalitis #BrainHealth neurology.org/doi/10.1212/NX… Nico Lundahl Alberto Vogrig

Congratulations to Dr. Luca Marsili, MD and Drs. Matteo Bologna Lucia Ricciardi on the publication of “Il Volto delle Neuroscienze" or The Faces of Neuroscience. The face, a window to emotions, enables the study of perception & processing of such emotions & production of movements

Call for abstracts is open! Deadline: Sept 5, 2025 📍 Congress on Autoimmune Encephalitis & Paraneoplastic Neurological Syndromes 🗓️ Sept 18–19, 2025 – Lyon 🇫🇷 🔗 Submit, register & view the program: betpsy-congres.com

A fantastic course organized by Rosa Cortese and Alvino Bisecco, featuring brilliant speakers and some of the best students. AINI Summer School Neuroimaging in Neuroimmunology Siena – 17–18 July 2025 The charm of the Tuscan landscape was the cherry on top! NINA - Italian Autoimmune Neurology Network

💥 Immune checkpoint inhibitors can trigger or worsen paraneoplastic neurologic syndromes. This study focuses on CV2/CRMP5-PNS patients treated with ICIs & compares outcomes with ICI-naïve cases. 📖 Read more 👉 neurology.org/doi/10.1212/NX… #NeuroOncology #PNS #NeuroTwitter #ICI

Yogeshwar et al. present clinical and MRI data from 127 patients with anti-IgLON5 disease. They show brain atrophy patterns that closely mirror sites of autoantibody binding and tau accumulation, with the location of atrophy linked to specific symptoms. tinyurl.com/3u4ufv2z