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Don't forget to submit your poster abstract for the 17th annual Tri-Institutional Chemical Biology Symposium! The deadline to submit an abstract is THIS FRIDAY, Aug 13th. Register here (it's free!): chembio.triiprograms.org/publications-n… Submit your abstract here: docs.google.com/forms/d/e/1FAI…

#tpcbsymposium is starting!!

Amazing talk by TPCB student Lauren Vostal from Rockefeller University Kapoor lab at NYAS chemical biology discussion group year-end symposium today.

Join us for our Tri-Institutional Chemical Biology Symposium on September 8th! Keynotes by Angela Koehler, Scheuring Lab, @LabPinkett, and Matthew Bogyo! Registration required, poster abstract deadline is Wednesday 8/31. Register for free: bit.ly/TPCB2022 #tpcbsymposium

Excited to share that I will be joining the Department of Biochemistry and Molecular Biology in the Rutgers Robert Wood Johnson Medical School this October! My lab will focus on single-molecule approaches to understanding the dynamics of ribosome biogenesis in health and disease.

Adi Berman, a TPCB student in Dr. Tarun Kapoor’s lab, is up next! #tpcbsymposium #microtubule Adi Berman

The Mickolajczyk Lab Rutgers - RWJMS Office for Research is hiring! We are looking for both a postdoc and a research specialist to join us in using single-molecule techniques to study ATPase motor proteins in ribosome biogenesis. Please RT and share! jobs.rutgers.edu/postings/185185 jobs.rutgers.edu/postings/185189

Very excited to finally be able to share our lab's new preprint article focused on the erasure mechanism of histone H3 monoaminylation modifications. A brief 🧵 biorxiv.org/cgi/content/sh…

It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.

Our latest review, written by graduate student Natalie Jones, is online! Click below to learn how genetic approaches can help us more effectively use chemical probes and test therapeutic hypotheses: authors.elsevier.com/a/1hIt7,LqArQC…

Congratulations to Adi Berman on her successful thesis defense! As per lab tradition, we made her a balloon hat to represent her work on the g-TURC. Best of luck in your future endeavors, Adi!

We are excited to share our latest preprint on bioRxiv: biorxiv.org/content/10.110… Graduate student Jared Ramsey led this collaborative effort in which we identify covalent allosteric inhibitors for helicases, enzymes notoriously difficult to selectively target.

How can AAA mechanoenzymes be activated by small molecules? In our latest preprint, we report the discovery of a druggable allosteric site for a chemical activator of the AAA protein VCP, and uncover unexpected mimicry of allosteric regulation by this small molecule.

Congratulations to Natalie Jones for her successful thesis defense! We are looking forward to following your future success as a postdoc and beyond. Just like Aqua, we are "calling Dr. Jones"! youtube.com/watch?v=-1jPUB…

👀 Preview of Nguyen et al: Fine-tuning chemical genetics to identify physiologic drug targets by Lauren Vostal and Tarun M. Kapoor at Rockefeller University TPCB dlvr.it/Syyxx7

We are excited to share our preprint reporting the structure of a γ-TuRC-capped microtubule, which reveals how free γ-TuRC, an inefficient nucleator with a splayed conformation, transforms into a cap that sets the 13 protofilament microtubule architecture biorxiv.org/content/10.110…

Super excited to see my most recent work (and first paper!) from the Kapoor Lab online J. Am. Chem. Soc.! By taking advantage of electrophilic 'scout fragments', we identify allosteric inhibitors of helicases, enzymes that have been challenging to target. pubs.acs.org/doi/epdf/10.10…

We are pleased to share our latest preprint on bioRxiv! Led by graduate student Lauren Vostal, we use chemical proteomics to profile VCP-DUB interactions in living cells. We identify DUBs that bind the entry, exit, or both sites of VCP's central pore. biorxiv.org/content/10.110…

Vostal et al Kapoor Lab Rockefeller University report two structures of complexes formed by VCP, an unfoldase, & VCPIP1, a deubiquitinase, & suggest that VCPIP1 is poised to cleave #ubiquitin from protein substrates that translocate through VCP’s central pore hubs.la/Q03bV3G00

Structural insights into the coupling between VCP, an essential unfoldase, and a deubiquitinase. New study from Lauren Vostal, Tarun Kapoor Kapoor Lab and colleagues Rockefeller University: hubs.la/Q03bVk850 #StructuralBiology #Biochemistry #ProteinHomeostasis #CryoEM