🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlocking high-throughput functional TCR screening from single-cell data. 🧵Koch Institute at MIT Michael Birnbaum MIT ChemE Dept Massachusetts Institute of Technology (MIT) biorxiv.org/content/10.110…

Out today from the Ruan lab! ChAIR, a droplet-based tri-omic tool, enables the simultaneous profiling of the transcriptome, chromatin accessibility and chromatin conformation in single cells. nature.com/articles/s4159…

Caillier, Patrick Oakes et al. find that T cells form #integrin mediated focal adhesions to pull themselves through confined spaces. hubs.la/Q03jXT9J0 📕 In Immune Cell Biology 2025: hubs.la/Q03jXWHM0 #AAI2025

Congrats, John Ngo the 2025 ACS Synthetic Biology Young Innovator!!! Come see him at #SEED Boston University Biomedical Engineering

These look amazing!!!! Honored to receive one :)

#OPENACCESS: Study shows that, compared with cancer-associated fibroblasts, leader tumor cells rely on actin-based protrusions to invade more effectively but deform collagen less than CAFs, which use myosin-based force. ow.ly/TlLG50VOnKG

Ivaska Lab Michael Bannister.bsky.social uncovers FUNCTIONAL role for TNS1 condensates as reservoirs of inactive adhesion proteins under the control of p38, ERK and AKT. Protein-release from condensates ➡️adhesion dynamics, filopodia, cell migration, invasion biorxiv.org/content/10.110…

An innovative genome-editing tool promises to do what original CRISPR systems have struggled to achieve: insert entire genes, precisely and efficiently, into human DNA go.nature.com/430GeeB

The leading edge of a crawling cell videoed through a microscope. Watch the actin cytoskeleton in motion as it drives membrane protrusion and cell movement. It’s like watching the cell think with its feet. #CellBiology

🚨 TOMORROW IS GENOME ENGINEERING DISCOVERY NIGHT! Learn how Center for Genome Engineering scientists are creating and deploying genetically modified cells to develop regenerative therapeutics! Free and open to all ages! 📆 May 23 from 4-6 p.m. 🔗 Register today: bit.ly/3H5mVbz.

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes Nature Communications nature.com/articles/s4146…

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Congratulations to all involved! Structural insights into the activation and inhibition of the ADAM17–iRhom2 complex | PNAS pnas.org/doi/10.1073/pn…

Latest from the lab:🧬Decoy DNA🧬can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging - simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie.2…

The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress. ascb.org/science-policy…

July 1…. Notch your average day. 11 year anniversary of the lab. 11th PhD student graduating this week. Promoted to full professor. 4 year DGS term is OVER! Feeling lucky despite all of the chaos. #gordonlabpuns

Domain analysis identifies a discrete nucleic acid-binding domain (NBD) within SUZ12 responsible for constraining PRC2 activity. CryoEM studies showed the NBD in close proximity to nucleic acids. Loss of this region (NEC, VEFS) causes global H3K27me3 hypermethylation. 11/13

🧬 Wondering what the future holds for T cell cancer therapies? We wrote an editorial for Science Magazine about how AI—like AlphaFold—is accelerating the design of T cell receptors (TCR), powering the next-generation of anti-tumor therapies. Read here! science.org/doi/10.1126/sc…

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Cytotoxic T cells (magenta) killing lymphoma cells (cyan) over the course of an hour. Target death seen by “popping” of the nucleus (yellow). Left one struggles; right one kills with ease. Open research question: why do some T cells kill better than others? 3-channel volumes