#Tumor cells can be tricky and good at evading the #ImmuneSystem, but an exciting new therapy can help target those cells for destruction. “We suspect that this could lead to deeper and longer responses for cancer patients,” UCSF’s Charles Craik says. ucsfh.org/3xpMRXv

Two drugs are better than one—blocking drug action in the periphery while maintaining CNS pharmacology (mTOR, Lrrk2 and Her2). #Glioblastoma Ziyang Zhang and Waweisslab.UCSF.edu UCSF Helen Diller Family Comprehensive Cancer Ctr HHMI College of Chemistry michaeljfox.org nature.com/articles/s4158…

Amazing day 1 at #QBIChemBio22 with ~500 chemical biologists from UC San Francisco College of Chemistry Sarafan ChEM-H

Congrats to Barry for the awoken "sleeping beauty"! Congrats to @CarolynBertozzi -- seeing her group started from UCB when I was a graduate and being amazed ever since! Thanks all for the great chemistries for our chemical biologists.

Our latest #research with Yin Shen on creating covalent linkages between proteins and RNAs, published with Springer Nature in [Nature Chemistry], allowing one to irreversibly lock proteins with bound RNA in vivo for researching and engineering. rdcu.be/cW2bZ

Our latest #research on creating covalent linkages between proteins and carbohydrates, published with Springer Nature in Nature Chemistry, allowing one to irreversibly lock proteins with bound carbohydrates for researching and engineering. rdcu.be/cXgml

We feel so very honored! Lucky to apply click chemistry to glycobiology; both fields are pioneered by this year's Nobel Laureate!

When two seasons collide ❄️🍁 One of my favorite photos I’ve ever taken

Amazing science and tremendous impact! Congrats to Kevan! Science World Honors Kevan Shokat for High-Impact Cancer Research cancer.ucsf.edu/news/2023/02/1…

We have developed a covalent nanobody that binds its target irreversibly via PERx. Using this nanobody as delivery vehicle for radionuclides enhances PET imaging and antitumor effects! Thanks to fantastic colleagues at UCSF. Paul Klauser Michael Evans pubs.acs.org/doi/10.1021/ac…

What if we have AI as editors!

How does proximity-enabled SuFEx (the new generation of click chemistry) behave in protein context? - find out in Chemical Science pubs.rsc.org/en/content/art… Chemical Science Paul Klauser

The forefront of click chemistry, Phosphorus fluoride exchange (PFEx), reaches new heights in protein environments! Our research reveals PFEx activates through proximity, showing unique properties. dlvr.it/T3fcWL Chem

Biospecific Chemistry allows for the selective covalent targeting of endogenous biomacromolecules in vivo without altering the biomacromolecules themselves. pubs.acs.org/doi/full/10.10…

Calling all chemists, biologists, geneticists: Dr. Lei Wang (Lei Wang) discusses biospecific chemistry, covalent targeting, and new pathways for biological and genetic research, today at 2 p.m. ET—an NIH lecture. Check it out here: go.nih.gov/qHZIhSM. #Biotech

Our department is hiring! Ladder Rank Faculty Position – Assistant, Associate, or Full Professor: We seek creative, innovative scientists who define and address fundamental questions in diverse areas relevant to our Department. aprecruit.ucsf.edu/JPF05273.

Arginine Accelerates Sulfur Fluoride Exchange and Phosphorus Fluoride Exchange Reactions between Proteins (Lei Wang and co-workers) Lei Wang #openaccess onlinelibrary.wiley.com/doi/10.1002/an…

The first session ‘Cell surfaces and their interactions’ features talks from @CarolynBertozzi, Zev Gartner, Balyn Zaro Zaro Lab, Lei Wang Lei Wang & Aashish Manglik

Lei Wang Lei Wang & Aashish Manglik

Each year, we highlight companies that received sizeable early-stage funding in the previous year. Enlaza Therapeutics is developing protein-based therapeutics that bind irreversibly to their target go.nature.com/4gzF8eR