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Trying something new for our lab outing! #watchout #axethrowing #badaxe

Many months & edits later, our work on the baseline SARS-CoV-2 spike-reactive B cell repertoire is (finally!) out in Nature Communications. ⬇ Most interesting & relevant results below. It gets cool. ⬇ Marit van Gils 👩🏻‍🔬🦠🧬🔬 nature.com/articles/s4146… (1)

With the help of the very talented Julianna Han The Ward Lab, we found out that this IGHV1-69/IGKV3-11 B cell pairing exclusively targets an apical S2 domain, which is normally obscured on the prefusion spike trimer but might be present in open and/or aberrant conformations. (8)

Well done Alba and colleagues! Alba Torrents Scripps Research

Including lots of work from our lab members Wilma Lee and Jon Torres. nsEM getting the job done!

So proud of you Hailee Perrett! Keep up the great work. We are lucky to have you.

Keep an eye out for cool science coming from the Murin lab!

Many scientists are working toward the gold standard of infectious disease prevention: universal vaccines. But what does that mean? A quick intro! (& as always, a huge shoutout to Matt, Faith, and Drew—teamwork makes the dream work!) Scripps Research youtube.com/watch?v=1ROgFu…

Beautiful work done by our Post Doc Gregory Martin and team including Jon Torres, Grace Gibson, Wilma Lee, Jeffrey Copps. 😍 #thatcryotho #malaria #cryoEM

Outstanding work from Hailee Perrett and Philip Brouwer, go check out the paper and the beautiful Lassa GPC figures. Congrats to all involved!

Great talk from Julianne and work from Team Flu!

And here's a short video what we're doing for a universal, variant-proof Covid vaccine, via joint efforts of immunology and structural biology, with @DennisRBurton and Ian Wilson, The Ward Lab youtube.com/watch?v=O2d8jG…

Two studies from Prof. Bill Schief’s lab & collaborators describe an approach to design a custom HIV vaccine that can coax the immune system to produce the right broadly neutralizing antibodies in a stepwise manner scripps.edu/news-and-event… Immunity Ragon Institute Moderna

Another malaria CSP antibody story describing the structural basis of how unique homotypic interactions in the L9 antibody result in a potent and protective phenotype! #malaria #cryoEM. Now available in BioRxiv biorxiv.org/content/10.110…

A new endowed fund set up by Prof. Andrew Ward is helping up-and-coming scientists from under-represented backgrounds to enroll in university without the worries of financial insecurity. Congratulations to inaugural recipient Alesandra Rodriguez magazine.scripps.edu/profiles/2022/… The Ward Lab

New in Science: Researchers have determined the cryo–electron microscopy structure of the hepatitis C virus E1E2 glycoprotein complex. The structure provides a blueprint for the design of vaccines and drugs that target the virus. scim.ag/jP

Incredible work from Philip, Antanasijevic Lab @ EPFL, Rogier Sanders (Amsterdam UMC) and more! Officially out in Cell Host & Microbe. We describe the presentation of Lassa GPC on nanoparticles and show it can induce neutralizing responses at a novel epitope. Full story: cell.com/cell-host-micr…

Featured Article: Lassa GPC nanoparticles- path to a vaccine? Stabilized #Lassa virus glycoprotein nanoparticle vaccine induces potent #antibody responses in rabbits & protects guinea pigs from #Lassavirus challenge The Ward Lab Antanasijevic Lab @ EPFL Brouwer & Sanders cell.com/cell-host-micr…

Holding it together: Nanoparticle stabilization of LASV trimer. Bonnie Gunn examines work of Antanasijevic Lab @ EPFL The Ward Lab using two-component nanoparticle strategy that enables stable trimeric presentation of #Lassavirus glycoprotein complex & induction of bnAbs cell.com/cell-host-micr…

Congratulations to new U.S. National Science Foundation #GRFP fellows: Gabrielle in the Constantinides Lab, Jared in the lab of Luke Lairson, Alexandra Salazar in the Lander Lab, Leigh in the The Ward Lab and Noah in the Matt Disney!