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B Cells Promote T Cell Immunosenescence and Mammalian Aging Parameters biorxiv.org/content/10.110… Nearly a decade of work in my lab: T cell aging is highly influenced by B cells. Special thanks to Saad Khan , Mainak Chakraborty , and teams Buck Institute , University Health Network and collaborators.

Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway journals.aai.org/jimmunol/artic…

As we mourn loss of and celebrate life of Judy Campisi, enjoy listening to interview she did for our podcast. It’s great tutorial on #cellularsenescence and her comment on “failed experiments” is classic Judy. Details about memorial service are pending buckinstitute.org/podcasts/under…

Oxidized Low-Density Lipoprotein Accumulation in Macrophages Impairs Lipopolysaccharide-Induced Activation of AKT2, ATP Citrate Lyase, Acetyl–Coenzyme A Production, and Inflammatory Gene H3K27 Acetylation journals.aai.org/immunohorizons…

It is my pleasure to share my 1st independently led primary research pub w/ Dan and Shawn Winer With many pointing out the leaky gut + dysbiosis that come with Alzheimer’s disease,we set out to investigate changes in the gut immune system in a mouse model of AD biorxiv.org/content/10.110…

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice biorxiv.org/content/10.110…

#Spacetravel is not anti-aging intervention. Buck scientists show how #immunesystem goes awry during #microgravity. Study in Nature Communications highlights implications for #aging here on Earth and provides insight into interventions for those in both locations buckinstitute.org/news/buck-rese…

Papers from our Space Omics and Medical Atlas (SOMA) package, built upon the extraordinary data from the Inspiration4 mission with SpaceX are now coming online. With more civilian crews going to space, this is truly the opening of the Second Space Age: nature.com/articles/s4158…

Thanks NASA GeneLab for all the great work to get the data online!

Buck scientists Dr. David Furman and Dr. Dan Winer are proud to be part of this important work Dan and Shawn Winer

Immunology of spaceflight nature.com/articles/s4152… nature.com/articles/s4146… nature.com/articles/s4146… nature.com/articles/s4146…

One of the most detailed analyses of immune system in microgravity and spaceflight ever done. Via AI, we found space nutraceuticals for future space travel. Thanks Furman Lab Afshin Beheshti Chris Mason SpaceX Elon Musk NASA nature.com/articles/s4146…

A Second Space Age Spanning Omics, Platforms, and Medicine Across Orbits disq.us/t/4p37q7t

nature.com/articles/s4200…

This is our first major paper of the lab showing early life modulation of T1D development, linked to maternal IgA deficiency. Super proud of the work twitterless Erinnand Luisa have done!

The inflammaging clock strikes IL-11! Immunity Dan and Shawn Winer cell.com/immunity/fullt… Spotlight on nature nature.com/articles/s4158…

The inflammaging clock strikes IL-11!: Immunity cell.com/immunity/fullt…

Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts biorxiv.org/content/10.110…

doi.org/10.1186/s12979… Great review on the role of antibodies in obesity and aging pathology.

📢New Recommended Reading📖 Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts Huixun Du & Daniel A. Winer (Dan and Shawn Winer) et al. link.springer.com/article/10.100… #tissuestiffness